ID F6R2F0_HORSE Unreviewed; 437 AA.
AC F6R2F0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
GN Name=CLN3 {ECO:0000313|Ensembl:ENSECAP00000015483.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015483.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015483.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015483.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015483.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015483.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the battenin family.
CC {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
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DR RefSeq; XP_001502160.1; XM_001502110.4.
DR AlphaFoldDB; F6R2F0; -.
DR STRING; 9796.ENSECAP00000015483; -.
DR PaxDb; 9796-ENSECAP00000015483; -.
DR Ensembl; ENSECAT00000018947.4; ENSECAP00000015483.3; ENSECAG00000017435.4.
DR GeneID; 100064282; -.
DR KEGG; ecb:100064282; -.
DR CTD; 1201; -.
DR GeneTree; ENSGT00390000003249; -.
DR HOGENOM; CLU_029663_0_1_1; -.
DR InParanoid; F6R2F0; -.
DR OMA; WLCNWQV; -.
DR OrthoDB; 2912995at2759; -.
DR TreeFam; TF314055; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000017435; Expressed in trophoblast and 23 other cell types or tissues.
DR ExpressionAtlas; F6R2F0; baseline.
DR GO; GO:0044754; C:autolysosome; IEA:Ensembl.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005795; C:Golgi stack; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
DR GO; GO:0120146; F:sulfatide binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0001508; P:action potential; IEA:Ensembl.
DR GO; GO:0042987; P:amyloid precursor protein catabolic process; IEA:Ensembl.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0097352; P:autophagosome maturation; IEA:Ensembl.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IEA:Ensembl.
DR GO; GO:0043534; P:blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:0046474; P:glycerophospholipid biosynthetic process; IEA:Ensembl.
DR GO; GO:0046836; P:glycolipid transport; IEA:Ensembl.
DR GO; GO:0090160; P:Golgi to lysosome transport; IEA:Ensembl.
DR GO; GO:0009992; P:intracellular water homeostasis; IEA:Ensembl.
DR GO; GO:0035235; P:ionotropic glutamate receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1903826; P:L-arginine transmembrane transport; IEA:Ensembl.
DR GO; GO:0007042; P:lysosomal lumen acidification; IBA:GO_Central.
DR GO; GO:0035752; P:lysosomal lumen pH elevation; IEA:Ensembl.
DR GO; GO:1905146; P:lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0045861; P:negative regulation of proteolysis; IEA:Ensembl.
DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR GO; GO:0090384; P:phagosome-lysosome docking; IEA:Ensembl.
DR GO; GO:0090385; P:phagosome-lysosome fusion; IEA:Ensembl.
DR GO; GO:0044857; P:plasma membrane raft organization; IEA:Ensembl.
DR GO; GO:2001288; P:positive regulation of caveolin-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0042998; P:positive regulation of Golgi to plasma membrane protein transport; IEA:Ensembl.
DR GO; GO:0048549; P:positive regulation of pinocytosis; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:1900079; P:regulation of arginine biosynthetic process; IEA:Ensembl.
DR GO; GO:1901096; P:regulation of autophagosome maturation; IEA:Ensembl.
DR GO; GO:0016243; P:regulation of autophagosome size; IEA:Ensembl.
DR GO; GO:0106049; P:regulation of cellular response to osmotic stress; IEA:Ensembl.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0010762; P:regulation of fibroblast migration; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:1905244; P:regulation of modification of synaptic structure; IEA:Ensembl.
DR GO; GO:1905162; P:regulation of phagosome maturation; IEA:Ensembl.
DR GO; GO:0070613; P:regulation of protein processing; IEA:Ensembl.
DR GO; GO:0048172; P:regulation of short-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
DR GO; GO:0036359; P:renal potassium excretion; IEA:Ensembl.
DR GO; GO:0047496; P:vesicle transport along microtubule; IEA:Ensembl.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; BATTENIN; 1.
DR PANTHER; PTHR10981:SF0; BATTENIN; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU361113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361113}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 97..121
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 127..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 211..229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 280..297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 343..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 437 AA; 47593 MW; 47E42377662E9A5A CRC64;
MGGCAGSRRR LSHSEEETAP EPRPPLLDRK GVDWKNAVGF WLLGLCNNFS YVVMLSAAHD
ILSHQRAPGN QSHVDPGPTP TPHNSSSRFD CNPVSTAAVL LADILPTLVI KLLAPLGLHL
LPYSPRVFVS GVCAAGSFIL VAFSHSVGTS LCGVVLASIS SGLGEITFLS LTAFYPRAVI
AWWSSGTGGA GLLGALSYLG LTQAGLSPQH TLLSMLGIPA LMLASYFFLL TSPGPQDPGG
EEEAETAARQ PLISSEAPEL KPDYSPNLSL QERWTVFKGL LWHIIPLVVV YFAEYFINQG
LFELLFFRNT SLSHAQQYRW YQMLYQAGVF ASRSSLRCCR IRFTWALALL QCLNLAFLLV
DVWFSFLPSI YLVFLIILYE GLLGGAAYVN TFHNIALETS DEHREFAMAA ACISDTLGIS
LSGLLALPLH DFLCHLS
//
