ID F6R657_MACMU Unreviewed; 940 AA.
AC F6R657;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Integrator complex subunit 4 {ECO:0000313|Ensembl:ENSMMUP00000013230.3};
GN Name=INTS4 {ECO:0000313|Ensembl:ENSMMUP00000013230.3,
GN ECO:0000313|VGNC:VGNC:73646};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000013230.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000013230.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000013230.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F6R657; -.
DR SMR; F6R657; -.
DR Ensembl; ENSMMUT00000014127.4; ENSMMUP00000013230.3; ENSMMUG00000010120.4.
DR VEuPathDB; HostDB:ENSMMUG00000010120; -.
DR VGNC; VGNC:73646; INTS4.
DR eggNOG; KOG2259; Eukaryota.
DR GeneTree; ENSGT00390000010128; -.
DR HOGENOM; CLU_012910_1_0_1; -.
DR TreeFam; TF315047; -.
DR Proteomes; UP000006718; Chromosome 14.
DR Bgee; ENSMMUG00000010120; Expressed in ileum and 23 other cell types or tissues.
DR ExpressionAtlas; F6R657; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR PANTHER; PTHR20938:SF0; INTEGRATOR COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR20938; UNCHARACTERIZED; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF20168; PDS5; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
SQ SEQUENCE 940 AA; 105526 MW; 1BBE1071F3FB25B1 CRC64;
MAAHLKKRVY EEFTKVVQQQ QEEIATKKLR LTKPSKSAAL HIDLCKATSP ADALQYLLQF
ARKPVEAESV EGVVRILLEH YYKENDPSVR LKIASLLGLL SKTAGFSPDC IMDDAINILQ
NEKSHQVLAQ LLDTLLAIGT KLPENQAIQM RLVDVACKHL TDTSHGVRNK CLQLLGNLGS
LEKSVTKDAE GLAARDVQKI IGDYFSDQDP RVRTAAIKAM LQLHERGLKL HQTIYNQACK
LLSDDYEQVR SAAVQLIWVV SQLYPESIVP IPSSNEEIRL VDDAFGKICH MVSDGSWVVR
VQAAKLLRKR TAHERAKELY SSGEFSSGRK WGDDAPKEEV DTGAVNLIES GACGAFVHGL
EDEMYEVRIA AVEALCMLAQ SSPSFAEKCL DFLVDMFNDE IEEVRLQSIH TMRKISNNIT
LREDQLDTVL AVLEDSSRDI REALHELLCC TNVSTKEGIH LALVELLKNL TKYPTDRDSI
WKCLKFLGSR HPTLVLPLVP ELLSTHPFFD TAEPDMDDPA YIAVLVLIFN AAKTCPTMPA
LFSDHTFRHY AYLRDSLSHL VPALRLPGRK LVSSAVSPSI ISQEDPSQQF LQQSLERVYS
LQHLDPQGAQ ELLEFTIRDL QRLGELQSEL AGVADFSATY LRCQLLLIKA LQEKLWNVAA
PLYLKQSDLA SAAAKQIMEE TYKMEFMYSG VENKQVVIIH HMRLQAKALQ LIVTARTTRG
LDPLFGMCEK FLQEVDFFQR YFIADLPHLQ DSFVDKLLDL MPRLMTSKPA EVVKILQTML
RQSAFLHLPL PEQIHKASAT IIEPAGESDN PLRFTSGLVV ALDVDATLEH VQDPQNTVKV
QVLYPDGQAQ MIHPKPADFR NPGPGRHRLI TQVYLSHTAW TEACQVEVRL LLAYNSSARI
PKCPWMEGGE VSPQVETSIE GTIPFSKPVK VYIMPKPARR
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