ID F6R8F4_HORSE Unreviewed; 1161 AA.
AC F6R8F4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=DENN domain containing 5B {ECO:0000313|Ensembl:ENSECAP00000010861.3};
GN Name=DENND5B {ECO:0000313|Ensembl:ENSECAP00000010861.3,
GN ECO:0000313|VGNC:VGNC:17128};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010861.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010861.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010861.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010861.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010861.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR AlphaFoldDB; F6R8F4; -.
DR Ensembl; ENSECAT00000013666.3; ENSECAP00000010861.3; ENSECAG00000012573.3.
DR VGNC; VGNC:17128; DENND5B.
DR GeneTree; ENSGT00940000153678; -.
DR HOGENOM; CLU_004201_2_0_1; -.
DR TreeFam; TF313237; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000012573; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6R8F4; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17691; RUN1_DENND5B; 1.
DR Gene3D; 1.20.58.900; -; 2.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047293; RUN1_DENND5B.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..500
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 691..851
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 855..963
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 1037..1161
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
SQ SEQUENCE 1161 AA; 132528 MW; D35815CA8DA485A3 CRC64;
MPKGLSFRTQ TDNKDPQFHS FIITREDGSR TYGFVLTFYE EVTSKQICTA MQTLYQMHNA
EHYSSVYASS SCSMDSLASS LDEGDTTSLL KLQRYNSYDI SRDTLYVSKS ICLITPLPFM
QACKKFLIQL YKAVTSQQPP PLPLESYIHN ILYEVPLPPP GRSLKFYGVY EPVICQRPGP
NELPLSDYPL REAFELLGLE NLVQVFTCVL LEMQILLYSQ DYQRLMTVAE GITTLLFPFQ
WQHVYVPILP ASLLHFLDAP VPYLMGLQSK EGTDRSKLEL PQEANLCFVD IDNHFIELPE
EFPQFPNKVD FIQELSEVLL QFGIPPEGSL HCSESATKLK NLVLKDLVND KKNGNVSANS
ISMYELLKGN ETIARLQALA KRTGVTVEKT DLSAPLGEKE KDLKLQCEEA ELRDYQLNVQ
LREVFANRFT QMFADYEAFV IQTAQDMESW LTNREQMQNF DKASFLSDQP EPYLPFLSRF
IETQMFATFI DNKIMSQWEE KDPLLRVFDS RIEKIRLYNV RAPTLRTSIY QKCSTLKEAA
QSIEQRLMKM DHTAIHPHLL DMKIGQGKYE QGFFPKLQSD VLATGPTNNN RWVSRSATAQ
RRKERLRQRS EHIGLDNDLR EKYMQEARSL GKNLRQPKLS DLSPAVIAQT NWKFVEGLLK
ECRMKTKRML VEKMGHEAVE LGHGEANITG LEENTLIASL CDLLERIWSH GLQVKQGKSA
LWSHLIQFQD REEKQEHLAE SPVALGPERR KSDCGVMLPT LRVSLIQDMR HIQNMSEIKT
DVGRARAWIR LSLEKKLLSQ HLKQLLSNQP LTKKLYKRYA FLRCEEEREQ FLYHLLSLNA
VDYFCFTSVF TTIMIPYRSV IIPIKKLSNA ITTSNPWICV SGELGDTGVM QIPKNLLEMT
FECQNLGKLT TVQIGHDNSG LLAKWLVDCV MVRNEITGHT YRFPCGRWLG KGIDDGSLER
ILIGELMTSA ADEDLVKQCR TPPQQKSPTT ARRLSITSLT GKNAKPNAGQ IQEGIGEAVN
NIVKHFHKPE KERGSLTLLL CGENGLVAAL EQVFHHGFKS ARIFHKNVFI WDFIERAVAY
FETTDQILDS EDDVLIQKSS CKTFCHYVNA INTAPRNIGK DGKFQIFVCL GTRSPTRDSG
WAGYGCPCHE RHTAGCSVRM S
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