ID F6REK1_HORSE Unreviewed; 736 AA.
AC F6REK1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSECAP00000010352.2};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSECAP00000010352.2,
GN ECO:0000313|VGNC:VGNC:15495};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010352.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010352.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010352.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010352.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010352.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR AlphaFoldDB; F6REK1; -.
DR STRING; 9796.ENSECAP00000010352; -.
DR PaxDb; 9796-ENSECAP00000010352; -.
DR Ensembl; ENSECAT00000013081.3; ENSECAP00000010352.2; ENSECAG00000011914.3.
DR CTD; 9459; -.
DR VGNC; VGNC:15495; ARHGEF6.
DR GeneTree; ENSGT00940000158723; -.
DR HOGENOM; CLU_017010_1_1_1; -.
DR InParanoid; F6REK1; -.
DR OMA; ITGNMVE; -.
DR OrthoDB; 2879064at2759; -.
DR TreeFam; TF316105; -.
DR Proteomes; UP000002281; Chromosome X.
DR Bgee; ENSECAG00000011914; Expressed in articular cartilage of joint and 21 other cell types or tissues.
DR ExpressionAtlas; F6REK1; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0030032; P:lamellipodium assembly; IBA:GO_Central.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..736
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040294337"
FT DOMAIN 120..179
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 201..381
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 403..508
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 75..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 678..719
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 76..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 736 AA; 82710 MW; 21524E0DC65BC839 CRC64;
MRSVAAAATP RLLLLPRLPG LPLPLLLLCP APLSLPVPTS AIQVFDPDDL FSGVNFSKVL
STLLAVNKAT EDQLSERPCA RSSSLSAANS SQTNPQGAVS STAPGLQRQS KPVEMTENGS
HQLIVKARFN FKQTNEDELS VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKSS
ERPLSPKAVK GFETTPLTKN YYTVVLQNIL DTERDYAKEL QSLLVTYLRP LQSNNNLSSV
EFTSLLGNFE EVCTFQQTLC QALEECSKFP ENQHKVGGCL LNLMPHFKSM YLAYCANHPS
AVNVLTQHSD DVEQFMESQG ASSPGILMLT TSLSKPFMRL EKYVTLLQEL ERHMEDTHPD
HQDILKAIIA FKALMGQCQD LRKRKQLELQ ILSEPIQAWE GEDIKTLGNV IFMSQVMVQY
GTCEEKEERY FLLFSTVLIM LSASPRMSGF IYQGKIPIAG MMVTRLDEIE GNDCTFEITG
NIIERIVVHC NNNQDFQEWL EQLYKLIRGP ASCGSLSKTS SSSCSAHSSF SSTGQPRGPL
EPPQIIKPWS LSCLRPAPPL RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKPS
EEEYVIRKST AALEEDAQIL KVIEAYCTSA NFQQGHGSSA RKDSVPQVLL PEEEKLIIEE
TRSNGQTIIE EKSLVDTVYA LKDEVKELKQ ENKRMKQCLE EELKSRRDLE KLVRRLLKQT
DECIRSESSS KTSILP
//
