ID F6RG11_CALJA Unreviewed; 277 AA.
AC F6RG11;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Thioredoxin-related transmembrane protein 1 {ECO:0000313|EMBL:JAB24539.1, ECO:0000313|Ensembl:ENSCJAP00000084595.1};
GN Name=TMX1 {ECO:0000313|EMBL:JAB24539.1,
GN ECO:0000313|Ensembl:ENSCJAP00000084595.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB24539.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000084595.1, ECO:0000313|Proteomes:UP000008225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB24539.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB05318.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB24539.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB17375.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB34230.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000084595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GAMT01006543; JAB05318.1; -; mRNA.
DR EMBL; GAMS01005761; JAB17375.1; -; mRNA.
DR EMBL; GAMR01009393; JAB24539.1; -; mRNA.
DR EMBL; GAMQ01007621; JAB34230.1; -; mRNA.
DR RefSeq; XP_002753945.1; XM_002753899.4.
DR STRING; 9483.ENSCJAP00000067314; -.
DR Ensembl; ENSCJAT00000139998.1; ENSCJAP00000084595.1; ENSCJAG00000048070.2.
DR GeneID; 100390293; -.
DR KEGG; cjc:100390293; -.
DR CTD; 81542; -.
DR eggNOG; KOG0913; Eukaryota.
DR GeneTree; ENSGT00940000155959; -.
DR HOGENOM; CLU_069292_2_1_1; -.
DR OMA; KYHGART; -.
DR OrthoDB; 2909094at2759; -.
DR TreeFam; TF106376; -.
DR Proteomes; UP000008225; Chromosome 10.
DR Bgee; ENSCJAG00000048070; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IEA:Ensembl.
DR GO; GO:0090331; P:negative regulation of platelet aggregation; IEA:Ensembl.
DR CDD; cd02994; PDI_a_TMX; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46107; DUMPY: SHORTER THAN WILD-TYPE; 1.
DR PANTHER; PTHR46107:SF2; THIOREDOXIN-RELATED TRANSMEMBRANE PROTEIN 1; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..277
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015091071"
FT TRANSMEM 178..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..132
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT REGION 212..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 31567 MW; AD839F174E817AA7 CRC64;
MAPSGSLAVP LAVLVLLLWG PPWTHGRRSN VRVITDENWR ELLEGDWMIE FYAPWCPACQ
NLQPEWESFA EWGEDLEVNV AKVDVTEQPG LSGRFIITAL PTIYHCKDGE FRRYQGPRTK
KDFINFISDK EWKSIEPVSS WFGPDSVLMS SMSALFQLSM WIRTCHNYFI EDLGLPVWGS
YTIFALVTLL SGLLLGLCMI FVADCLCPSK RRRPQPYPSK KLSESVKPLK KVEEEQEADE
EDVSEEEAER KEGTNKDFPQ NAIRQRSLGP SSATDKS
//
