ID   F6RG50_ORNAN            Unreviewed;      1064 AA.
AC   F6RG50;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=BUB1 mitotic checkpoint serine/threonine kinase B {ECO:0000313|Ensembl:ENSOANP00000016996.2};
GN   Name=BUB1B {ECO:0000313|Ensembl:ENSOANP00000016996.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000016996.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000016996.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000016996.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; F6RG50; -.
DR   STRING; 9258.ENSOANP00000016996; -.
DR   Ensembl; ENSOANT00000016999.3; ENSOANP00000016996.2; ENSOANG00000010717.3.
DR   eggNOG; KOG1166; Eukaryota.
DR   GeneTree; ENSGT00940000158912; -.
DR   HOGENOM; CLU_010890_0_0_1; -.
DR   InParanoid; F6RG50; -.
DR   OMA; QPWMAPP; -.
DR   OrthoDB; 5479089at2759; -.
DR   TreeFam; TF105456; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000010717; Expressed in fibroblast and 4 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0033597; C:mitotic checkpoint complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000940; C:outer kinetochore; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0005819; C:spindle; IEA:Ensembl.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   GO; GO:0051754; P:meiotic sister chromatid cohesion, centromeric; IBA:GO_Central.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR   GO; GO:0071459; P:protein localization to chromosome, centromeric region; IEA:Ensembl.
DR   Gene3D; 1.25.40.430; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015661; Bub1/Mad3.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR013212; Mad3/Bub1_I.
DR   PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR   PANTHER; PTHR14030:SF25; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA; 1.
DR   Pfam; PF08311; Mad3_BUB1_I; 1.
DR   SMART; SM00777; Mad3_BUB1_I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS51489; BUB1_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN          49..208
FT                   /note="BUB1 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51489"
FT   REGION          242..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          469..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          676..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          423..453
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        250..264
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1064 AA;  117801 MW;  45A1B89FC09E10AA CRC64;
     MAQGGDEWEL SKENVQPLRQ GRIMSTLQGA LAQQETTSYS TIQQQKQAFE SEIRFYTGDD
     PLDVWDRYIR WIEQTFPQGG KESKLSALLE RAVKVLQEER RYYNDPRFLS LWLKLGHTCN
     EPLDMYSYLH SQGIGIGLAQ LYIAWAEAYE VREDYRKAEQ VFQKGLQCKA EPQDRLQSQH
     RQFQARVSRQ TLWALERGGE EEEEEVEEVE DWALGPHRTS LAELKSRGKK TARAPINRVG
     GALRGQSRGL PNTAPPQRPN GSQFMVFDEN GGGPSWTEPP GLSTQPWAAP PVPRDKENEL
     KPGPWNNARL PEPPRWSAAS VAAAAPALPG FTPYVEESAQ QQVMTPCKIE PSINHVLSTW
     KPGKEAGDAL QRVQSHQKEA HEKKEVVMYC KEKVYASVEE FSLEEIRAEI WWKKLNKKRD
     EELLAREHKR AEMQKQIEQM EQLLKEIKAT QEQRPGDELA VRELIQKASS LGPAPEPQET
     PEDTVPASTQ YPEGAPAEQL FGPQRASLQT DNGRQNWPCP LGADPLDSGG SGVPFSIFDE
     SEAGNNPCAS LPANPQQLPT RRRPLAVRRH SEGIASKDDG TPEATGELVG VEPLSEEAII
     TGSYRNVTIC PDPEDTCDFL QAAHLASTPF HGVVALNGPL AGDAKRVPQE AVGSHAVREA
     TYPEELTNKK LSPIMEESSQ EMTRSSGALG SSSSSVSGLS TIKDLQIPEK LELANETEGA
     VSSSVLQAET SPPSPWCPEQ HRRLLVSLPE LSSFPGFCSE PGPMPEVEVD KVVKLGKESY
     CIKKAVLTGD ACKTFWGVQI DSSCVALKAV AIKVYSQPAP WDFYITVRLK ERLEAEFGWG
     FSERCSCLHF QDGCIVLHQD LNPFTLSDLL PHTESNAHEL ALLVAHTLLG LVEKLQRADI
     VHGDLSPQTL ILGDRICAGF HCAEDSSVLR IVDFSHAVDL RARPGIRSLG GFPTVQALEG
     QKILAHCTSP YQVDLLGIAD VAHLLLFREH LQVRQAGSHW TLSQNLSGLK GGGLWKAFFE
     RILNADGEAS VSVVSELRQG LNEKLDSCWS SLQAAFWELE GLLS
//