ID F6RIP1_MACMU Unreviewed; 1852 AA.
AC F6RIP1;
DT 30-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=NLR family CARD domain containing 5 {ECO:0000313|Ensembl:ENSMMUP00000001041.4};
GN Name=NLRC5 {ECO:0000313|Ensembl:ENSMMUP00000001041.4,
GN ECO:0000313|VGNC:VGNC:75285};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000001041.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000001041.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000001041.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMMUT00000001112.4; ENSMMUP00000001041.4; ENSMMUG00000000769.4.
DR VEuPathDB; HostDB:ENSMMUG00000000769; -.
DR VGNC; VGNC:75285; NLRC5.
DR GeneTree; ENSGT00940000160652; -.
DR Proteomes; UP000006718; Chromosome 20.
DR Bgee; ENSMMUG00000000769; Expressed in colon and 20 other cell types or tissues.
DR ExpressionAtlas; F6RIP1; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.533.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041210; NLRC5_atypical_Card.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF284; RIBONUCLEASE_ANGIOGENIN INHIBITOR 1; 1.
DR Pfam; PF18461; Atypical_Card; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR SMART; SM00367; LRR_CC; 10.
DR SMART; SM00368; LRR_RI; 18.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 3.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 222..349
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 102..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1852 AA; 203145 MW; 7DB176429F3E777C CRC64;
MDPIDLQLGN KNLWSCLVRL LSKDPEWLNA KMKFFLPNTD LDSRNETLDP EQRVILQLNK
LHVQGSATWQ SFIHCVCMQL EVPLELEVLL LSTFGCDDGK GRSQIPRPGS STPSFAFSGL
KRPHQSCGSS PRRKQCRKQQ LELAKKYLQL LRTSAQQRYG SRIPGSGQPH ALHQVYVPPI
LRRATASLDT QEGAIMGDLK VEDGTDVSIS DLFNTRVNKG PRVTVLLGKA GMGKTTLAHR
LCQKWAEGHL DCFQALFLFE FRQLNLITRF LTLSQLLFDL YLSPESDPDA VFQYLEKNAD
QVLLIFDGLD EALQPMGPDG PGSVLTLFSR LCRGTLLPGC RVMATSRPGK LPACLPAEAA
TVYMLGFDGP RVEEYVNHFF SAQPLQEGAL AELQTNGRLR SLCAVPALCQ VACLCLHHLL
PDHAPGQSVA LLPTMTQLYM QMVLALSPRG HLPTTSLLDL GEVALRGLET GKVIFYAKDI
APPLIAFGAT HSLLTSFCVR TGPGHQQTGY AFTHVSLQEF LAALHLMASP KVDKDTLTQH
VTLHSRWVQR TKARLDLSDH LPTFLAGLAS CTCRPFLSHL AQGNEDCVGT KQAAVVQVLK
KLATRKLTGP KVVELCHCVN ETQEPELASL TAQSLPYQLP FHNFPLTCTD LATLTNILEH
REAPIHLDFD GCPLEPHCPE ALVGCGQIEN LSFKSRKCGD AFAEALSRSL PTMGRLQMLG
LAGSKITARG ISHLVKALPL CPQLEEVSFR DNQLSDQVVL NIVEVLPHLP RLRKLDLSGN
SVCVSTLLCL ARVAVTCPTI RTLQARKADL IFLLSPPTET TAELQRAPDL QESDGQRKGA
QSRSLTLRLQ KCQLQVHDAE TLIALLQEGP HLEEVDLSGN QLEDEGCRLM AEAASQLHIA
RKLDLSDNGL SLAGVHCVLR AVSACWTLAE LHISLRHKTV VFMFAQEPEE QEGPQERAAF
LDSLMLQMPS ELPLSSRRMR LTHCGLQAKH LEQLCKALGG SCHLGHLHLD FSGNALGDEG
ATRLAQLLPG LGALQSLNLS ENGLSLDAVL GLARCFSTLQ WLFHLDISFE SQHILLRGDK
TGRDIWATGS SPDFPAGAEF LGFRRRCIPR SLRLSECPLE PPSLTHLCAT LKECPGPLEL
QLSCEFLSDQ SLETLLDCLP RLPQLSLLQL NQTGLSPKSP FLLANTLSLC PRVKKVDLRS
LHHATLHFRS NEEQEGVCCG RFTGCSLSQE HVESLCRLLS KCKDLSQVDL SANLLGDSGL
RCLLECLPQV PISGSLDLSH NSVSQESALY LVETLPSCPR VREASVNLGS EQSFRIHFSK
EDQAGKTLRL SECSFRPEHV SRLATGLSQS LQLTELTLTQ CCLDQEQLAI LLSLVGRPAG
LFSLRVQEPW ADRAGILSLL EVCAQASGSV TEISISKTQQ QLCVQLEFPR QEENPEAVAL
RLAHCDLGTH HSLLVGQLME TCARLQQLRS APGNSTQGSR LTCCPLTPTR LTSSCVSTEG
LAHLASGLGH CHHLEELDLS NNQFDEEGTK ALMRALEGKW MLKRLDLGHL LLNSSALTLL
THGLSHMTRL QSLRLKRNSI GDVGCCHLSE ALRAATSLEE LDLSHNQIGD AGVQHLATIL
PGLPELRKID LSVNSISPAG GMQLAESLIL CRHLEELMLG CNALGDPTAL GLARELPQHL
RVLHLPFSHL GPGGALSLTQ ALDGSPHLEE ISLAENNLAG GVLHFCKELP LLRQIDLVSC
KIDNQTIKLL TSSFTRFLSW LSWNLLGDEA AAELAQVLPQ MGRLKRVDLE KNQITAFGAW
LLAEGLAQGS SIQVIRLWNN PIPCDMAQRL KSQEPRLDFA FFDNQSQAPW GT
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