ID F6RJG8_HORSE Unreviewed; 924 AA.
AC F6RJG8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Sad1 and UNC84 domain containing 1 {ECO:0000313|Ensembl:ENSECAP00000015400.2};
GN Name=SUN1 {ECO:0000313|Ensembl:ENSECAP00000015400.2,
GN ECO:0000313|VGNC:VGNC:23758};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000015400.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000015400.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015400.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000015400.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000015400.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6RJG8; -.
DR Ensembl; ENSECAT00000018854.3; ENSECAP00000015400.2; ENSECAG00000017201.4.
DR VGNC; VGNC:23758; SUN1.
DR GeneTree; ENSGT00940000155830; -.
DR OMA; LLWEQVQ; -.
DR OrthoDB; 39017at2759; -.
DR TreeFam; TF323915; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000017201; Expressed in endometrium and 23 other cell types or tissues.
DR ExpressionAtlas; F6RJG8; baseline.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:Ensembl.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR GO; GO:0140444; F:cytoskeleton-nuclear membrane anchor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005521; F:lamin binding; IEA:Ensembl.
DR GO; GO:0051642; P:centrosome localization; IEA:Ensembl.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR GO; GO:0070197; P:meiotic attachment of telomere to nuclear envelope; IEA:Ensembl.
DR GO; GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IEA:Ensembl.
DR GO; GO:0021817; P:nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration; IEA:Ensembl.
DR CDD; cd21439; SUN1_cc1; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR045119; SUN1-5.
DR InterPro; IPR032680; SUN1_N.
DR InterPro; IPR040994; Sun_CC2.
DR InterPro; IPR012919; SUN_dom.
DR PANTHER; PTHR12911; SAD1/UNC-84-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR12911:SF23; SUN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF18580; HTH_SUN2; 1.
DR Pfam; PF09387; MRP; 1.
DR Pfam; PF07738; Sad1_UNC; 1.
DR PROSITE; PS51469; SUN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 357..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 762..923
FT /note="SUN"
FT /evidence="ECO:0000259|PROSITE:PS51469"
FT REGION 308..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 566..635
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 466..480
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 102583 MW; 1B1770055CE3C742 CRC64;
MDFSRLHMYT PPQCVPENTG YTYALSSSYS SDALDFETEH KLDPVFDSPR MSRRSLRLVT
TACATEEGQA GDAPSCPSSA ASLRDRAART AKQRRSASKL AFSVNHASGK AVSLAVGRRG
SGGLQGAACL QPPVLDESLI REQTKVDHFW GLDDDGDLKG GSEAAVQGNG DLAARSNGFT
CRDCSLLSGR EDALTTLPVA HGTSSRVYSR DRTQKRGASF CVDRIWWLAK YTSSSFSSFL
VQLFQVVLMK LNYESENYKL KSYESKDRES ESYKSKSRES TAHSSYCGRV NVTELFREDG
RLGVHGESLC DDSKGQKRPD THAAVHSPSS RPGGAAGPAG RGLAHAGRLL MQTLRRIGAA
GWFVLKAVLS VVWLAVVAPG KAASGVLWWL GIGWYQLVTL ISWLNVFLLT RCLRNICKFL
ILVIPLLLLL GAGLSLWGQG DFRSFLPLLN WTHMYGAQRP SEPRNTLTPA APPPARPPEA
GDEAFPRLQM SEVERQMTFL SGQCHSHDQK LRELTVLIQE LQAQVHQMDA GSEGVLPLVK
RVVEQRLKEV RADVPSGSAT DYMTFHQDHE LRISNLEEIL GRMTERSEAI QRELEQTKQR
TMSGADEGRR LLSVVEHLEL ELGHLQAELS DWQRLKAPCE SADSVHEQVD ARVRETLKLM
FSGDEQDASL EWLLQKFSSQ FVSKDDVQVL LRDLELQILK NITHHISVTK QMPTSETVVS
AVNEAGISGI TEAQARAIVD NALKLYSQDK TGMVDFALES GGGSILSTRC AETYETKTAL
LSLFGIPLWY FSQSPRVVIQ PDIYPGNCWA FRGSQGYLVV RLSMQIRPTT FTLEHIPKTL
SPTGNITSAP KDFAVYGLEN EYQEEGELLG RFTYDQDGES LQMFPVPKRP EGAFQIVELR
ILSNWGHPEY TCLYRFRVHG EPVE
//
