ID   F6RK11_CALJA            Unreviewed;       518 AA.
AC   F6RK11;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Unc-5 family C-terminal like {ECO:0000313|Ensembl:ENSCJAP00000007352.2};
GN   Name=UNC5CL {ECO:0000313|Ensembl:ENSCJAP00000007352.2};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000007352.2, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000007352.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000007352.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844}.
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DR   RefSeq; XP_002746564.1; XM_002746518.3.
DR   RefSeq; XP_008992633.1; XM_008994385.2.
DR   AlphaFoldDB; F6RK11; -.
DR   STRING; 9483.ENSCJAP00000007352; -.
DR   Ensembl; ENSCJAT00000007769.5; ENSCJAP00000007352.2; ENSCJAG00000004044.5.
DR   GeneID; 100400498; -.
DR   KEGG; cjc:100400498; -.
DR   CTD; 222643; -.
DR   eggNOG; KOG1480; Eukaryota.
DR   GeneTree; ENSGT00950000182815; -.
DR   HOGENOM; CLU_040040_0_0_1; -.
DR   InParanoid; F6RK11; -.
DR   OMA; VTRQLMH; -.
DR   OrthoDB; 5252769at2759; -.
DR   TreeFam; TF316767; -.
DR   Proteomes; UP000008225; Chromosome 4.
DR   Bgee; ENSCJAG00000004044; Expressed in liver and 2 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:Ensembl.
DR   GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF41; UNC5C-LIKE PROTEIN; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          102..237
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          415..494
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          492..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   518 AA;  57719 MW;  1417ACB7B1A8809E CRC64;
     MCPQESSFQP SQFLLLVGVP VASVLLLAQC LRWHCPRRLL QACWMPNGQE EPVSQPTPPP
     EDEVSRQHLP ATLPELAAFY QELHTPTQGQ TVVRQLMHKL LVFSAREVDH RGGCLMLQDT
     GISLLIPPGA VAVGRQERVS LILVWDLSDA PSLSRAQGLV SPVVACGPHG ASFLKPCILT
     FKHCAQQPSQ ARTYSSNTAL LDAKVWRPLG RPGTHASRDE CRIHLSHFSL YTCVLEAPVG
     REARKWLQLA IFCSPLAPGQ SHLQLRVYFL NNTPCALQWA LTNEQPHGGR LRGPCQLFDF
     TGARGDQCLK LTYISEGWEN VDDSSCQLVP HLHIWHGKCP FRSFCFRRKT ASENEDCSAL
     ANEIIVTMHT FQDGLETKYM EILRFQASEE ESWAAPPPVS QPPPCNRLPP ELFEQLQMLL
     EPNSITGNDW RRLASHLGLC GMKIRFLSCQ RSPAAAILEL FEEQNGSLQE LHYLMTVMER
     LDCASAIQNY LNGTQGGSPG PQRGGAQDNQ GLEMDEKL
//