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Database: UniProt
Entry: F6RKH3_HORSE
LinkDB: F6RKH3_HORSE
Original site: F6RKH3_HORSE 
ID   F6RKH3_HORSE            Unreviewed;      1047 AA.
AC   F6RKH3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 4.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
GN   Name=SMC5 {ECO:0000313|Ensembl:ENSECAP00000022595.4,
GN   ECO:0000313|VGNC:VGNC:23333};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022595.4, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000022595.4, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022595.4,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000022595.4}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022595.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC       {ECO:0000256|ARBA:ARBA00010171}.
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DR   AlphaFoldDB; F6RKH3; -.
DR   Ensembl; ENSECAT00000027014.4; ENSECAP00000022595.4; ENSECAG00000024999.4.
DR   VGNC; VGNC:23333; SMC5.
DR   GeneTree; ENSGT01100000263674; -.
DR   HOGENOM; CLU_004969_1_0_1; -.
DR   TreeFam; TF105708; -.
DR   Proteomes; UP000002281; Chromosome 23.
DR   Bgee; ENSECAG00000024999; Expressed in oviduct epithelium and 23 other cell types or tissues.
DR   ExpressionAtlas; F6RKH3; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR027131; SMC5.
DR   PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR   PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          54..998
FT                   /note="RecF/RecN/SMC N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02463"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          237..452
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          653..711
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          835..872
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1047 AA;  123127 MW;  A696D89C5E27D6B4 CRC64;
     MATPSRKTST PGPLASKRPL PRDPSSEVPS KRKSSAPPAP RPLQSSGPFV EGSIVRIAME
     NFLTYDVCEV APGPHLNMII GANGTGKSSI VCAICLGLAG KPAFMGRADK VGFFVKRGCS
     KGMVEIELFR TSGNLVITRE IDVAKNQSFW FINKKSTTQK VVEEQVAALN IQVGNLCQFL
     PQDKVGEFAK LSKIELLEAT EKSIGPPEMH RYHCELKNFR EKEKQLETSC KEKTEYLEKM
     IQRNERYKQD VERFYERKRH LDLIEMLEAK RPWVEYENVR QEYEEVKLAR DRVKEEVRKL
     KEGQIPMTLR IEEIEKQRHN LEARIKEKAT DIKETSQKCK QRQDVIERKD KHIEELQQAL
     TVKRNEEHDR QRRISNTRKM IEDLQNELKT TENCENLQPQ IDAITNDLRR VQDEKALCEG
     EIIDKRREKE TLEKEKKNVE EHIVRFDNLM NQKEDKLRQR YRDTYDAVLW LRNNRNKFKQ
     RVCEPIMLTI NMKDNKNAKY VENHIPLNDL RAFVFESQED MEVFLREVRD NKKLRVNAVV
     APRVSHADRA PSRSLNELKP YGFFSYLREL FDAPDPVMSY LCCQYHIHEV PVGTERTRER
     IERVIQETRL KQIYTAEEKY VVKTSFYSNK VISINTSLKV AQFLTVTVDL EQRRHLEEQL
     KEINKKLQAV ESDLIALHET NKRLEHKDNE LRQKKKELLE RKTKKRQLEQ KISSKLGSLK
     LMEQDTCNLE EEERKASAKI KEIHVQKAKL VTELTDLIKQ HFIELDENRQ RLLQKCKELM
     KRARQVCNLG AEQTVPQEYQ TAFQDLPNTL DEIDALLTEE RSRASCFTGL NPTVVEEYTK
     REEEIEQLTE ELKIKKVELD QYRESISQVK ERWLNPLKEL VEKINEKFSN FFSSMQCAGE
     VDLHTENEED YDKYGIRIRV KFRSSTQLHE LTPHHQSGGE RSVSTMLYLM ALQELNRCPF
     RVVDEINQGM DPINERRVFE MVVNTACKEN TSQYFFITPK LLQNLPYSEK MTVLFVYNGP
     HMLEPNRWNL KAFQRRRRRI TFTQPSQ
//
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