ID   F6RQU0_ORNAN            Unreviewed;       517 AA.
AC   F6RQU0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 77.
DE   RecName: Full=Pleckstrin homology domain-containing family A member 8 {ECO:0000256|ARBA:ARBA00016588};
DE   AltName: Full=Phosphatidylinositol-four-phosphate adapter protein 2 {ECO:0000256|ARBA:ARBA00031032};
GN   Name=PLEKHA8 {ECO:0000313|Ensembl:ENSOANP00000017160.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017160.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000017160.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017160.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000256|ARBA:ARBA00004198}.
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DR   AlphaFoldDB; F6RQU0; -.
DR   STRING; 9258.ENSOANP00000017160; -.
DR   Ensembl; ENSOANT00000017163.2; ENSOANP00000017160.2; ENSOANG00000010831.4.
DR   eggNOG; KOG3221; Eukaryota.
DR   GeneTree; ENSGT00940000157288; -.
DR   HOGENOM; CLU_039839_0_0_1; -.
DR   OrthoDB; 642641at2759; -.
DR   TreeFam; TF317467; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000010831; Expressed in fibroblast and 8 other cell types or tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0120013; F:lipid transfer activity; IEA:InterPro.
DR   CDD; cd01247; PH_FAPP1_FAPP2; 1.
DR   Gene3D; 1.10.3520.10; Glycolipid transfer protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR036497; GLTP_sf.
DR   InterPro; IPR014830; Glycolipid_transfer_prot_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10219; GLYCOLIPID TRANSFER PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10219:SF43; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8; 1.
DR   Pfam; PF08718; GLTP; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF110004; Glycolipid transfer protein, GLTP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          1..93
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          226..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   517 AA;  57650 MW;  5B18DA84EE8E058C CRC64;
     MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHPADNTR
     MDLIIPGEQY FYLKARNVAE RQRWLVALGS AKACLTDSRA QKEKEFTENT ETLKTKMSEL
     RLYCDLLVQQ VDKTREATAA GVSGSEEGID VGALLRSTCN TFLKTLEECM QIANTTFTSE
     LLYPTPPGSP RLAVLKPSKM KHPIIPIHNP VERQMELNSC ENGSLNVEVT DSEPTPVTNE
     TPSDLKLAEN DGTMSAEESS GQETKQAGER GISPASGRCD NDLMPPGGDF LSESTKSQRE
     EEKEEVRTFF SAMNTSFSDI ELLEDSGIPT EAFLESCYAV VPVLDKLGPT VFAPVKMDLV
     GNIKKVNQKY ITNKEEFTTL QKIVLHEVNA NVAQIRNSAT EALLWLKRGL KFLKGFLTEV
     KNGEKDIQTA LNNAYGKTLR QHHGWVVRGV FALALRAAPS YEDFVAALTV REGDDQKEAF
     SIGMERDLNV YLPAMEKQLE ILDTLYEVHG LESDEVV
//