ID F6RR59_ORNAN Unreviewed; 950 AA.
AC F6RR59;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Nucleotide binding oligomerization domain containing 1 {ECO:0000313|Ensembl:ENSOANP00000017157.2};
GN Name=NOD1 {ECO:0000313|Ensembl:ENSOANP00000017157.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017157.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017157.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017157.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; F6RR59; -.
DR STRING; 9258.ENSOANP00000017157; -.
DR Ensembl; ENSOANT00000017160.3; ENSOANP00000017157.2; ENSOANG00000010829.3.
DR eggNOG; KOG4308; Eukaryota.
DR GeneTree; ENSGT00940000157845; -.
DR HOGENOM; CLU_011291_1_0_1; -.
DR InParanoid; F6RR59; -.
DR OMA; AHWGMEK; -.
DR OrthoDB; 3087860at2759; -.
DR TreeFam; TF352118; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000010829; Expressed in endometrium and 8 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0050700; F:CARD domain binding; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0042834; F:peptidoglycan binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0071225; P:cellular response to muramyl dipeptide; IEA:Ensembl.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR GO; GO:0016045; P:detection of bacterium; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0070427; P:nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0098792; P:xenophagy; IEA:Ensembl.
DR CDD; cd08324; CARD_NOD1_CARD4; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF278; RNI-LIKE SUPERFAMILY PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 21..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 196..528
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 950 AA; 106505 MW; 75F21497A02F59DB CRC64;
MENRACFEAE LIPQSPRSFI KLLKVNRELL VTQIRNTQCL LDNLIENEYF STEDAEIAAA
SPTQPDKVRK ILDLVQSKGE EVSEYLIYVL QQVSDAYIDL KPWLSEICFS PSELIESKVV
VNTDPVSRYT QKLRCELGRD SKFIMSYAQK EEMLLEDTYT ENVMELINFS NESLGSVGDL
ASLLDSTTGV INEDGETVFV FGDAGVGKSI LLQKMQHLWA KGELGGGAKF FFRFRCRMFS
LFKESEVLCL KDLLFKHNCY PEQDPEEVFA FLLRFPHTAL FTFDGFDELH SDFDPGAVPE
ASSPVEPTHP LVLLVNLLSG KLLKGAGKVL TARAGTEVPR RLIRKKVLLR GFAPSHLRAY
TQRFFPDRAL RAQVQTQLEA NPNLSSLCSV PLFCWIIFKC FEHFHAAYDS PQGLPDCSVT
LTDVFLLVTE VHLNRALPAS LLRRNTRSQV QTLCAGRAAL QALGRVAYSG LERSLFVFDQ
EEVEALEVPE EDLQLGFVRA VPEAGDRLSY EFFHITLQSF FTALFLVVDD RVGSGELLRF
FGEWRTGGPA GPACPRLPFL SLRCLAGGGP SGEDPFRNND HFHFTNLFLC GLLSKAKQKL
LRHLAPASAL KKKRKALRAH LFSSMRAYLK SLPRCQTEMF NQVQAMPTFI WMLRCIYETQ
SDKVGQLAAR GICANYIKLT YCNACSADCS AISFVMHHFH KRLALDLDNN NLNDYGVKEL
RPCFSRLTVL RLSVNQITDT GVKVLYEELT KYKIVTFLGL YNNQITDVGA KYLARLMDEC
SSLTHLKLGA NKITSEGGKC LALAVQKSKS IFEIGMWGNK IGDEGAKAFA EALRNHPSLT
NLSLAFNGIS TEGGKSIAQA LQHNTSVRIF WLTKNELDDE VAESFAEMLE VNQTLTHLWL
IQNQITARGT TCLAGALQKN TGILEICLNG NLISPEEAKT FEDEKRIVCF
//