ID F6RSF0_XENTR Unreviewed; 132 AA.
AC F6RSF0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Cystatin-C {ECO:0000313|Ensembl:ENSXETP00000002319, ECO:0000313|RefSeq:XP_002934915.1};
GN Name=LOC100485774 {ECO:0000313|RefSeq:XP_002934915.1,
GN ECO:0000313|Xenbase:XB-GENE-29077991};
GN Synonyms=cst3 {ECO:0000313|Ensembl:ENSXETP00000002319};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000002319};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000002319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000002319};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000002319}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002934915.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002934915.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002934915.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cystatin family.
CC {ECO:0000256|ARBA:ARBA00009403}.
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DR RefSeq; XP_002934915.1; XM_002934869.4.
DR STRING; 8364.ENSXETP00000002318; -.
DR PaxDb; 8364-ENSXETP00000054610; -.
DR Ensembl; ENSXETT00000002319; ENSXETP00000002319; ENSXETG00000001063.
DR GeneID; 100485774; -.
DR KEGG; xtr:100485774; -.
DR Xenbase; XB-GENE-5873171; cst3.
DR Xenbase; XB-GENE-29077991; LOC100485774.
DR eggNOG; ENOG502SC50; Eukaryota.
DR HOGENOM; CLU_118168_0_0_1; -.
DR OMA; VKSSCQD; -.
DR OrthoDB; 3086783at2759; -.
DR Reactome; R-XTR-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR Reactome; R-XTR-6798695; Neutrophil degranulation.
DR Reactome; R-XTR-8957275; Post-translational protein phosphorylation.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000001063; Expressed in egg cell and 14 other cell types or tissues.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00042; CY; 1.
DR Gene3D; 3.10.450.10; -; 1.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR46186; CYSTATIN; 1.
DR PANTHER; PTHR46186:SF2; CYSTATIN-RELATED; 1.
DR Pfam; PF00031; Cystatin; 1.
DR SMART; SM00043; CY; 1.
DR SUPFAM; SSF54403; Cystatin/monellin; 1.
DR PROSITE; PS00287; CYSTATIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..132
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041157792"
FT DOMAIN 22..132
FT /note="Cystatin"
FT /evidence="ECO:0000259|SMART:SM00043"
SQ SEQUENCE 132 AA; 14382 MW; FA43223111BEF97F CRC64;
MDAAVVVMFL MVAAAASASR GTAVGGLRPA SVNEQGVQQA MAFAMEEYNK RSNDMFVNTI
TKVNGVTKQI VAGTLYRIDA DIARTECKKS AVGVQNCPLH TDPDFVKSMN CKFEVFSVPW
MRTISLEKHE CS
//
