ID F6RST6_CALJA Unreviewed; 938 AA.
AC F6RST6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN Name=PITRM1 {ECO:0000313|Ensembl:ENSCJAP00000042046.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000042046.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000042046.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000042046.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6RST6; -.
DR Ensembl; ENSCJAT00000061945.4; ENSCJAP00000042046.1; ENSCJAG00000020425.5.
DR GeneTree; ENSGT00390000018381; -.
DR HOGENOM; CLU_009165_1_0_1; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000020425; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 5.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 471..653
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 705..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 106066 MW; D39B4FF8F435512E CRC64;
RHVALRRAAR PAYAEAAERR VTSVPELFLT AVKLSHDDTG ARYLHLARED TNNLFSVQFR
TTPMDSTGVP HILEHTVLCG SQKYPCRDPF FKMLNRSLST FMNAFTASDY TLYPFSTQNP
KDFQNLLSVY LDATFFPCLR ELDFWQEGWR LEHENPSDPQ TPLVFKGVVF NEMKGVFTDN
ERIFSQHLQN RLLPDHTYSV VSGGDPLCIP ELTWEQLKQF HATHYHPSNA RFFTYGNFPL
EQHLKQIQEE ALSKFQKIEP STAVPAQTPW DKPREFQITC GPDSLATDPS KQRTVSVSFL
LPDITDTFEA FTLSLLSSLL ISGPNSPFYK ALIESGLGTD FSPDVGYNGY TREAYFSVGL
QGIAEKDIET VRSLVDRTID EVIEKGFEDE RIEALLHKIE IQMKHQSTSF GLTLTSYIAS
CWNHDGDPVE LLKLGNQLAK FRQCLQENPK FLEEKVKQYF KNNQHKLTLS MRPDDKYREK
QAQVEATKLK QKVEALSPRD RQQIYEKGLE LRTRQSKPQD ASCLPALKVS DIEPTIPATE
LDVVLTAGDI PVQYCSQPTN GMVYFRAFCS LNTLPEELRP YVPLFCSVLT NPCFEEEEHF
KVLVKMTAQE LANGIPDSGH LYASIRAGRT LTPAGDLREA FSGMDQVRLM KRIAEMTDIK
PILRKLPRIK KHLLNGDNMR CSVNATPQQM AETEKVVENF LRNIGRSKKE RRPVRPHVVE
KPAPSSPGGD AHTPNGSQII RKLVMEPTFK PWQMKTHFLM PFPVNYVGEC IRTVPYTDPD
HASLKILACL MTAKFLHTEI REKGGAYAGG AKLSHNGIFT FYSYRDPNTM ETLQSFGKAV
DWAKSGKFTQ QDIDEAKLSA FSTVDAPVAP SDKGMDHFLS GLSDDMKQAH REQLFAVSRD
KLLAVSDRYL GTGKSTHGLA ILGPENAKIA KDPSWIVS
//
