ID F6RUE4_MACMU Unreviewed; 954 AA.
AC F6RUE4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Smoothelin {ECO:0000313|Ensembl:ENSMMUP00000006215.4};
GN Name=SMTN {ECO:0000313|Ensembl:ENSMMUP00000006215.4,
GN ECO:0000313|VGNC:VGNC:77661};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000006215.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000006215.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000006215.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6RUE4; -.
DR SMR; F6RUE4; -.
DR Ensembl; ENSMMUT00000006606.4; ENSMMUP00000006215.4; ENSMMUG00000004675.4.
DR VEuPathDB; HostDB:ENSMMUG00000004675; -.
DR VGNC; VGNC:77661; SMTN.
DR GeneTree; ENSGT00940000161655; -.
DR Proteomes; UP000006718; Chromosome 10.
DR Bgee; ENSMMUG00000004675; Expressed in heart and 19 other cell types or tissues.
DR ExpressionAtlas; F6RUE4; baseline.
DR CDD; cd21259; CH_SMTNB; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR022189; SMTN.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR PANTHER; PTHR23167:SF52; SMOOTHELIN; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF12510; Smoothelin; 3.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 838..944
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 28..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 208..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..286
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 103062 MW; 3F2BFD1A9D649952 CRC64;
MRAVASGPGS RTFLRIGRGM VGMGAPGDLH AACPSTPAGT PSPRSRVPVR PPSLSWLEVT
ADLAERRRIR SAIRELQRQE LEREEEALAS KRFRAERQDN KENWLHSRQR EAEQRVALAR
LAGQLESMND VEELTALLRS AGEYEERKLI RAAIRRVRAQ EIEAATLAGR LCSARPNSGL
REDSKGRVAH RLEQCEVPER EEQEQQTEVS KPTPTPEGTS QDVTTVTLLL RAPPGSTSSS
PASASSSPTA ASPEPPLEPA EAQCLTAEVP GAPEPPPSPP KTTSPEPQES PTLTSTEGQV
VNKLLSGPKE TPAAQSPTRG PSDTKRADVA GPRPCQRSLS VLSPHQPAQN RESTPLASRP
SSFQRAGSVR DRVHKFTSDS LMAARLQDGT PRAALSPLTP ARLVGPSLTS TTPASSSSGS
SSRGRSDTSS RFSKEQQGVA QPLAQLRSCS QEEGPRGRGL APRPLENGAG GPVARSEEPG
APLPVAVSTA EPGGSMKTTF TIEIKDGRGQ ASTGRVLLPT GNQRAELTLG LRAPPTLLST
SSGGKSTITR VNSPGTLARL GSVTHVTSFS HAPPSSRGGC SVKMEPEPAE PPSAAVEAAN
GAEQTRVNKA PEGRSPLSAE ELMTIEDEGV LDKMLDQSTD FEERKLIRAA LRELRQRKRD
QRDKERERRL QEARGRPGEG RGNTATETTT RHSQRAADGS AVSTVTKTER LVHSNDGTRT
ARTTTVESSF VRRSENGSGS TMMQTKTFSS SSSSKKMGSI FDREDQTSPR AGSLAALEKR
QAEKKKELMK AQSLPKTSAS QARKAMIEKL EKEGAAGSPG GPRAAVQRST SFGVPNANSI
KQMLLDWCRA KTRGYEHVDI QNFSSSWSDG MAFCALVHNF FPEAFDYGQL SPQNRRQNFE
VAFSSAETHA DCPQLLDTED MVRLREPDWK CVYTYIQEFY RCLVQKGLVK TKKS
//
