ID F6RV85_HORSE Unreviewed; 697 AA.
AC F6RV85;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=XK-related protein {ECO:0000256|RuleBase:RU910716};
GN Name=XKR5 {ECO:0000313|VGNC:VGNC:55370};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010316.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010316.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010316.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010316.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010316.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU910716}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU910716}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000256|ARBA:ARBA00008789,
CC ECO:0000256|RuleBase:RU910716}.
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DR AlphaFoldDB; F6RV85; -.
DR PaxDb; 9796-ENSECAP00000010316; -.
DR Ensembl; ENSECAT00000013038.4; ENSECAP00000010316.3; ENSECAG00000012521.4.
DR CTD; 389610; -.
DR VGNC; VGNC:55370; XKR5.
DR GeneTree; ENSGT01070000253766; -.
DR HOGENOM; CLU_025738_1_0_1; -.
DR InParanoid; F6RV85; -.
DR OMA; RMATFYT; -.
DR OrthoDB; 3060440at2759; -.
DR TreeFam; TF316454; -.
DR Proteomes; UP000002281; Chromosome 27.
DR Bgee; ENSECAG00000012521; Expressed in articular cartilage of joint and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR PANTHER; PTHR16024; XK-RELATED PROTEIN; 1.
DR PANTHER; PTHR16024:SF15; XK-RELATED PROTEIN 5; 1.
DR Pfam; PF09815; XK-related; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU910716};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|RuleBase:RU910716};
KW Transmembrane helix {ECO:0000256|RuleBase:RU910716}.
FT TRANSMEM 34..57
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 207..225
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT REGION 337..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 75689 MW; 001C5170E0700462 CRC64;
MHAVVLGLSA LLLAADESAR LCTVVYYFSA GQLLWGGLAL AVLLPGCLVQ GLSYLWFRAD
GHQGHCLLVL LHGLQLGVWK RHWDAACTVL SKEWKASHRG QLLLQEADLS ALRLLEALLQ
AGPHLLLQTY VFLASDFTDV VPGVSALCSW SALSWALVCY ARSMDSMKPG RLSMPWAALL
CQQLWRMGML AARVLSLVLF FKTYHIWVLV VGGAHWLVMT FWLVAQQSDI IDSTCHWRLF
NLLVGAVYVF CYLNFWDSPS RNRMATFYTI MLLENVILLL LATDFLQGAS WTSLWTTAGA
LSGFLIGSVS LVIYYSLLHP KSTDICQGFV RESCDTSGGD KAERASSPWA TAPAGERPGS
PAESHEEGYE LTSLGKPPSP QWGPPEAGLE SQIVGEDSFL GHHHWLLMKL ALKTGNVSKI
NAAFGDNYPG CFCPPAWQLS QHYQQQKPPF SQQELPSLPH DLLTSEKGSE FQGIPKAASN
LLETSTYVSF ASDNHDDAPA QKLSATPQEG SPKEGAGAGS GTWGRGASGQ PRGGEGQESS
TLYFSATTEE VTCSNPEGGQ ATPKTLHSGR RLGKGSPAQL ASPRPATQPF PITMANISPI
LGTGPGRSFR PSAGFPGRAP GGSEREEQQE PTRNLNPSCT TGTQMSLPKA QRHSSLQVLL
VRSRKIQVEV LHLLSAYDIK REPGKRATLE DLVIAVL
//
