ID F6RWP2_CALJA Unreviewed; 536 AA.
AC F6RWP2; U3CMT6; U3DUQ1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Polypyrimidine tract-binding protein 2 {ECO:0000313|EMBL:JAB20522.1, ECO:0000313|Ensembl:ENSCJAP00000033602.4};
GN Name=PTBP2 {ECO:0000313|EMBL:JAB20522.1,
GN ECO:0000313|Ensembl:ENSCJAP00000033602.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000033602.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000033602.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB20522.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB52446.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB20522.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000033602.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GAMS01002614; JAB20522.1; -; mRNA.
DR EMBL; GAMP01000309; JAB52446.1; -; mRNA.
DR Ensembl; ENSCJAT00000035499.5; ENSCJAP00000033602.4; ENSCJAG00000018172.5.
DR eggNOG; KOG1190; Eukaryota.
DR GeneTree; ENSGT01050000244924; -.
DR HOGENOM; CLU_066655_0_0_1; -.
DR OMA; IHHVLYP; -.
DR TreeFam; TF319824; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000018172; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005681; C:spliceosomal complex; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0006376; P:mRNA splice site recognition; IEA:Ensembl.
DR GO; GO:0033119; P:negative regulation of RNA splicing; IEA:Ensembl.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:Ensembl.
DR CDD; cd12778; RRM1_PTBP2; 1.
DR CDD; cd12783; RRM2_PTBP2; 1.
DR CDD; cd12696; RRM3_PTBP2; 1.
DR CDD; cd12702; RRM4_PTBP2; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035002; PTBP2_RRM1.
DR InterPro; IPR034799; PTBP2_RRM3.
DR InterPro; IPR034800; PTBP2_RRM4.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF16; POLYPYRIMIDINE TRACT-BINDING PROTEIN 2; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 59..133
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 181..257
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 343..417
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 460..534
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 536 AA; 57928 MW; 9510D0E9AC2FCBD6 CRC64;
MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV
LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH
LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV
LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG
QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL
LGLPVAAVPG ALSPLAIPNA AAAAAAAAAG RVGMPGVSAG GNTVLLVSNL NEEMVTPQSL
FTLFGVYGDV QRVKILYNKK DSALIQMADG NQSQLAMNHL NGQKMYGKII RVTLSKHQTV
QLPREGLDDQ GLTKDFGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VAEEDLRTLF
ANTGGTVKAF KFFQDHKMAL LQMATVEEAI QALIDLHNYN LGENHHLRVS FSKSTI
//
