ID F6S1A4_HORSE Unreviewed; 137 AA.
AC F6S1A4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Poly(A) binding protein interacting protein 2B {ECO:0000313|Ensembl:ENSECAP00000010577.3};
GN Name=PAIP2B {ECO:0000313|Ensembl:ENSECAP00000010577.3,
GN ECO:0000313|VGNC:VGNC:51378};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000010577.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000010577.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010577.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000010577.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000010577.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PAIP2 family.
CC {ECO:0000256|ARBA:ARBA00006858}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6S1A4; -.
DR Ensembl; ENSECAT00000013331.3; ENSECAP00000010577.3; ENSECAG00000012841.3.
DR VGNC; VGNC:51378; PAIP2B.
DR GeneTree; ENSGT00390000017284; -.
DR HOGENOM; CLU_134152_0_0_1; -.
DR OMA; IPRSHIM; -.
DR OrthoDB; 2910584at2759; -.
DR TreeFam; TF326855; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000012841; Expressed in retina and 23 other cell types or tissues.
DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IEA:InterPro.
DR GO; GO:0045947; P:negative regulation of translational initiation; IEA:InterPro.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR040396; PAIP2-like.
DR PANTHER; PTHR13154; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR13154:SF5; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2B; 1.
DR Pfam; PF07145; PAM2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 120..136
FT /note="Ataxin-2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07145"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 137 AA; 15596 MW; 6588C449A6FD9021 CRC64;
MNAEEQALTT GSVMMNGSSV ANTSPSVKSK EDQGLDGHDE KENPFAEYMW MENEEDFNRQ
VEEELQEQDF LDRCFQEMLD EEDQDWFIPS RDLPQAMGQL QQQLNGLSVG DGHDSEDILS
KSNLNPDAKE FIPGVKY
//
