ID F6S1J7_HORSE Unreviewed; 2111 AA.
AC F6S1J7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Ral GTPase activating protein catalytic subunit alpha 1 {ECO:0000313|Ensembl:ENSECAP00000022549.3};
GN Name=RALGAPA1 {ECO:0000313|Ensembl:ENSECAP00000022549.3,
GN ECO:0000313|VGNC:VGNC:51652};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000022549.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000022549.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022549.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000022549.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000022549.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000026965.3; ENSECAP00000022549.3; ENSECAG00000024960.4.
DR VGNC; VGNC:51652; RALGAPA1.
DR GeneTree; ENSGT00950000183139; -.
DR HOGENOM; CLU_001676_0_0_1; -.
DR TreeFam; TF324484; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000024960; Expressed in brainstem and 23 other cell types or tissues.
DR ExpressionAtlas; F6S1J7; baseline.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 1871..2079
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 342..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2111 AA; 238082 MW; F697A55EB63DCCF3 CRC64;
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSA PQSEHGPRTL DNLINPPLNL
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL
FSHFKKYYLP YIFPNICKEN SLYHPVLDIP QMRPKPHYVM IKKDTETNEA IYCTKEPFIK
ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE AVPKNIQRAA ASLVSREENK SDNADKADRT
AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEEIVISSS DLPCIDSVTD RDISMEEGEK
REEENETSIA DHVRNSAWAK NGTYEDVLHN ASEEAIEQNT RAGTQAVLQV FIINSSNIFL
LEPANEIKNL LDEHTDMCKR ILNIYRFMVV QVSMDKKTWE QMLLVLLRVT ESVLKTPSQA
FLQFQGKKNM TLAGRLAGPL FQTLIVAWIK ANLNVYISRE LWDDLLSVLS SLTYWEELAT
EWSLTMETLT KVLARNLYSL DLSDLPLDKL SEQKQKKHKG KGVGHEFQKV SVDKSFSRGW
SRDQPGQAPM RQRSATTTGS PGTEKARSIV RQKTVAMRSR SIGECALPSA YIRSAKSAPV
LIHTSKPFLP DIVLTPLSDE LSDIDDAQIL PRPTRVRHFS QSEDTGNEVF GALNEEQPLP
RSSSTSDILE PFTVERAKDV HKGFMIANHE LSMEPLWTDY RKQDYVNKED MSPKLPPLNS
DIGSSNANVP DLMDEFIAER LRSGNASTMT RRGSSPGSLE IPKDLPDILN KQSQMRPIDD
PGVPSEWTSP ASAGSSDLIS SDSHSDSFSA FQYDGRKFDN FGFGADTGIV SSADVDSGSA
HHQSAEEQEV ASLTTLHIDS ETSSLNQQAF SAEVATVTGS ESASPIHSAL GSRSQTPSPS
TLNADHMEQK DLQLDEKLHH SVLQTPDDLE ISEFPSECCS VMAGGTLTGW HADVATVMWR
RMLGILGDVN AIMDPEIHAQ VFDYLCELWQ NLAKIRDNLG ISTDNLTSPS PPVLIPPLRI
LTPWLFKATM LTDKYKQGKL HAYKLICNTM KRRQDVSPNR DFLTHFYNIM HCGLLHIDQD
IVNTIIKHCS PQFFSLGLPG ATMLIMDFII AASRVASSAF LNAPRVEAQV LLGSLVCFPN
LYCELPALHP NIPDIAVSQF TDVKELIIKT VLSSARDEPS GPARCVALCS LGIWICEELV
HESHHPQIKE ALNVICVSLK FTNKTVAHVA CNMLHMLVHY VPRLQIYQPD SPLKIIQILI
ATITHLLPST EASSYEMDKR LVVSLLLCLL DWIMALPLKT LLQPVHATGA ENDKIEKSVL
NCIYKVLHGC VYGAQCFSNP KYFPISLSDL ASVDYDPFMH LESLKEPEPL HSPDSERSSK
LQPVTEVKTQ MQQGLISIAA RTVITHLVNH LGHYPMSGGP AMLTSQVCEN HDNHYSESTE
LSPELFESPN IQFFVLNNTT LVSCIQIRSE ESIPGGGLSA GLASANSNVR IIVRDLSGKY
SWDSAILYGP PPVSGLSEPT SLILSLSRQE KPEEPPPSNE CLEDITVKDG IPLQFKRRFR
ETVPTWDTIK DEEDVLDELL QYLGVTSPEC LQRTGISLNI PAPQPVCISE KQENDVINAI
LKQHTEEKEF VEKHFNDLNM KAVEQDEPTP QKPQSAFYYC RLLLSILGMN SWDKRRSFHL
LKKNEKLLRE LRNLDSRQCR ETHKIAVFYV AEGQEDKHSI LTNTGGSQAY EDFVAGLGWE
VNLTNHCGFM GGLQKNKSTG LTTPYFATST VEVVFHVSTR MPSDSDDSLT KKLRHLGNDE
VHIVWSEHTR DYRRGIIPTE FGDVLIVIYP MKNHMFSIQI MKKPEVPFFG PLFDGAIVNG
KVLPIMVRAT AINASRALKS LIPLYQNFYE ERARYLQTIV QHHLEPTTFE DFAAQVFSPA
PYHHLPSDAD H
//
