ID F6S5L9_CIOIN Unreviewed; 774 AA.
AC F6S5L9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000011338.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000011338.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}.
CC -!- SIMILARITY: Belongs to the CAS family. {ECO:0000256|ARBA:ARBA00007848}.
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DR EMBL; EAAA01001656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6S5L9; -.
DR STRING; 7719.ENSCINP00000011338; -.
DR Ensembl; ENSCINT00000011338.3; ENSCINP00000011338.3; ENSCING00000005491.3.
DR GeneTree; ENSGT00950000183008; -.
DR HOGENOM; CLU_017000_1_0_1; -.
DR InParanoid; F6S5L9; -.
DR OMA; QLANFIH; -.
DR TreeFam; TF328782; -.
DR Proteomes; UP000008144; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd11564; FAT-like_CAS_C; 1.
DR CDD; cd11549; Serine_rich_CAS; 1.
DR CDD; cd11844; SH3_CAS; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 1.
DR Gene3D; 1.20.120.830; Serine-rich domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR021901; CAS_C.
DR InterPro; IPR037362; CAS_fam.
DR InterPro; IPR014928; Serine_rich_dom.
DR InterPro; IPR038319; Serine_rich_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10654; CAS SCAFFOLDING PROTEIN; 1.
DR PANTHER; PTHR10654:SF18; IP17195P; 1.
DR Pfam; PF12026; CAS_C; 1.
DR Pfam; PF08824; Serine_rich; 2.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..62
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 68..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 86159 MW; BE3F58F5D8E9E357 CRC64;
LHVLAKAIYD NAAETEDEIT FNRGDIVTII EQNTAGLEGW WLCSLNGRQG IAPGNRLRIL
PGMYEGMQNS TGGTAPEETY DVPPTHYWNS PNPQIDQDEE YDIPRRQLPI NRNNNNGGLS
NQQSNSPTEI YDIPRPGAWR GNSVDGEEVY DVPQASAFAH ASKDEEQEVY DVPSSLTAVM
TPDPSDLYDV PPIVSRGPQS APEDVYDVPP RRTEPIDMDA MFNAMNPEDV YDVPPSTLRL
NTSTLSRSAG NVLDTFETPN SQPFPTQQES MDRDVVYDIP QSRLSSLRRM RREMNQVPDP
ISKPINENTD YIYDVPPQVT RDGSSKQKQT VAQKLSDEDV VDGLIRRLSL NEPSIEVKQN
NRLSVTSRES YSSYIDNTPG LFDELNIDVD VAVNKLIETK QELEDSVSNL LTLVKENWRK
PENISDKVDI VHTLFLKIMV AVNHFLTFAR GATANSVAVD RNGEARASKN VQLGLRKQLV
PIEEDLGMEN SEEVVLDAVD SFVMTSRAVS DDASQLANFI HSHIHVLFTS CSPNKSPVKS
STPVKPNKPF PQAIQALQAR PLPAVPASLQ QAQSQSTSNT IMLGEDAWLE DYDYVALQDK
DEFELSSHET SPMSGLNKRR TQIVTLDSKI ELKNNTAVFF NSKDREYLLS LKIDVPALIH
NLSKSIDRFV SAVDAGNPPH SFVPLGKYVI FSAHQLVFVG DSMCQRLQVE PVKQALQRQC
TNLCSILKRT VVATKGAALQ WPSVSAVQEM VDRMSEIATS AHQIRITLTP MLSN
//
