ID F6S5N0_HORSE Unreviewed; 522 AA.
AC F6S5N0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=EF-hand calcium binding domain 3 {ECO:0000313|Ensembl:ENSECAP00000006871.4};
GN Name=EFCAB3 {ECO:0000313|VGNC:VGNC:17440};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006871.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006871.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006871.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006871.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006871.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6S5N0; -.
DR STRING; 9796.ENSECAP00000006871; -.
DR PaxDb; 9796-ENSECAP00000006871; -.
DR Ensembl; ENSECAT00000009084.4; ENSECAP00000006871.4; ENSECAG00000008824.4.
DR VGNC; VGNC:17440; EFCAB3.
DR GeneTree; ENSGT00940000161358; -.
DR HOGENOM; CLU_055753_0_0_1; -.
DR InParanoid; F6S5N0; -.
DR OMA; QMQAFQD; -.
DR TreeFam; TF328393; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000008824; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR22656:SF1; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 13; 1.
DR PANTHER; PTHR22656; UNCHARACTERIZED; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 167..202
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 496..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 59903 MW; EF146089ACF06942 CRC64;
MTQLSIDDDR TVGLNDLMDA VSYIKGEVIE IQDLDNFLAS EGFELTKEEM KELMPHLTFT
GNGKVKVHSI MEGLKNFKHR VTGHMAVSDI KSKLKLNPLT KVPSYYGKRD KDLPGSPPCQ
LQHKERKLNA SQMQAFQDAY NYFNKDKTGC IDLHGMMCTL AKLGMNLTKH DVYNELRCAD
IDRDGKVNFS DFIKVLTDQN RFLKAVVPEK ETCLDLAGNP GILLFEILSK LVETSALPRK
AIMEIVSYFR RKFQETTSGI LWSPYAMGYG KRRLKPDICT PPSSSTAAFA SAARIAIMKE
KDLLKFLEEL KRCNPPSDSP YSKIPIFPLF PNVDGVVMGK PFRDLQKLEM LRRKEPLNFF
ENYFFHKRDW KTQAANIKPI EPNSGYPTDI LAIDQILKKK QNWTVTDAAA IKQHVKRATD
TYNLGTALEH RKEMLNLWQK IRGDLIGIDT KNESFYDTFS TYTWSWNVCQ ELLSPKDLRL
FDAYVNRNSF HNSVFSSSSD ISECDTETGR KRKRKRFKGF QQ
//
