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Database: UniProt
Entry: F6S6P9_HORSE
LinkDB: F6S6P9_HORSE
Original site: F6S6P9_HORSE 
ID   F6S6P9_HORSE            Unreviewed;       642 AA.
AC   F6S6P9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   31-JUL-2019, entry version 47.
DE   SubName: Full=Epsin 3 {ECO:0000313|Ensembl:ENSECAP00000003635};
GN   Name=EPN3 {ECO:0000313|Ensembl:ENSECAP00000003635,
GN   ECO:0000313|VGNC:VGNC:17633};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003635, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000003635, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003635,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000003635}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003635};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   PaxDb; F6S6P9; -.
DR   Ensembl; ENSECAT00000005184; ENSECAP00000003635; ENSECAG00000004484.
DR   VGNC; VGNC:17633; EPN3.
DR   eggNOG; KOG2056; Eukaryota.
DR   eggNOG; ENOG410XSM0; LUCA.
DR   GeneTree; ENSGT00940000158217; -.
DR   InParanoid; F6S6P9; -.
DR   OMA; ADPWSPI; -.
DR   OrthoDB; 1263849at2759; -.
DR   TreeFam; TF313361; -.
DR   Proteomes; UP000002281; Chromosome 11.
DR   Bgee; ENSECAG00000004484; Expressed in 3 organ(s), highest expression level in liver.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:Ensembl.
DR   GO; GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:1990175; F:EH domain binding; IEA:Ensembl.
DR   Gene3D; 1.25.40.90; -; 1.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR027318; Epsin-3_metazoa.
DR   InterPro; IPR003903; UIM_dom.
DR   PANTHER; PTHR12276:SF16; PTHR12276:SF16; 1.
DR   Pfam; PF01417; ENTH; 1.
DR   Pfam; PF02809; UIM; 2.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00726; UIM; 2.
DR   SUPFAM; SSF48464; SSF48464; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50330; UIM; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN       12    144       ENTH. {ECO:0000259|PROSITE:PS50942}.
FT   REGION      152    214       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      248    296       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      311    475       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      528    581       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      604    642       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    179    212       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    277    295       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    330    364       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    528    560       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    626    642       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   642 AA;  69082 MW;  E6409812E7AFEC47 CRC64;
     MTTSALRRQV KNIVHNYSEA EVKVREATSN DPWGPPSSLM SEIADLTFNT VAFAEVMGML
     WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL YTIQTLKDFQ YIDRDGKDQG
     VNVREKVKQV MALLKDEERL RQERTHALKT KERMALEGTG IGSGQLGFSR RHGDDYGRSR
     SSPSSYNSSS SSPRYTSDLE QARPQTSGEE ELQLQLALAM SREEAEKPVP PASHRDEDLQ
     LQLALRLSQQ EHEKEVRSWR GDDSPTANGA EAAARCWQDR EPAREERKEE KLKTSQSSIL
     DLADIFTAAP VPPSTHCSAD PWDIPGLRPS TEPSGSSWGP SADPWSPIPS GSALSRSQPW
     DLPPVLSSSE PWGRTPVLPA GLPSTDPWAQ KSPHHKLPNT GADPWGPSVE TSNKPALGGT
     STFDPFAKPP ESTETKEGLE HAQALPSGKP SSPVELDLFG DPIPSSKQNG TKEPDAFDLG
     ALEEALAQPS KEARACRTPE SFLGPSASSL VNLDSLVKVP QAAKTRNPFL TGLSAPSPTN
     PFGGGEQGRP TLNQMRSGSP ALGLASGGPV GAPSGSMTYS ASLPLPLSSV PAGVTLPASV
     SVFPQAGAFT PPPASLQQPL LPTSGSAGPL HPPPQASTNP FL
//
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