ID F6S7Y0_MONDO Unreviewed; 1990 AA.
AC F6S7Y0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Kinesin family member 13A {ECO:0000313|Ensembl:ENSMODP00000014035.4};
GN Name=KIF13A {ECO:0000313|Ensembl:ENSMODP00000014035.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000014035.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000014035.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000014035.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007487961.1; XM_007487899.2.
DR Ensembl; ENSMODT00000014294.4; ENSMODP00000014035.4; ENSMODG00000011220.4.
DR GeneID; 100025300; -.
DR CTD; 63971; -.
DR eggNOG; KOG0241; Eukaryota.
DR GeneTree; ENSGT00940000157508; -.
DR HOGENOM; CLU_001485_29_2_1; -.
DR OrthoDB; 126886at2759; -.
DR TreeFam; TF105221; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000011220; Expressed in heart and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22729; FHA_KIF13A; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF3; KINESIN FAMILY MEMBER 14-LIKE; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM01052; CAP_GLY; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 5..352
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1878..1920
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1516..1542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1633..1667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1763..1783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1929..1957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 364..409
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 646..673
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1516..1533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1652..1667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1929..1946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 102..109
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1990 AA; 223370 MW; E4F46075F5C0823B CRC64;
MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC
FWSMDETNTT KYAGQEEVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGNAEQLG
LIPRLCCALF QRISLEQNES QIFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP
YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIVT QTLYDLQSGN
SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKNK
FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE
DPNARVIREL REEVEKLKEQ LSQAEAMKAP ELKEKLEESE KLIKELTVTW EEKLRKTEEI
AQERQKQLES MGISLETSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RIGADTSQDI
QLFGIGIQPE HCEIDIAPDG DVSLTPKESA RSCVNGTLVC CATQLWHGDR ILWGNNHFFR
INLPKRKRRD WLKDLEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNGGFPI
NLYSWWSSRW WSYLKIFFPL MWLQTELLHK RWDKDPVQNV VQVLEKQYLE EKRSALEEQR
MMYERELEQL RQQLSPERQH QNSGSDRLTF TGQTAQQKVT LWAEERDELF RQSLAKLREQ
LVKANTLVRE ANFLAEEMNK LTDYQVTLQI PAANLSANRK RGAIVSEPAI QVRRKGKSTQ
VWNIEKLENK LIDMRDLYQE WKEKVPEVKR LYGKRGDPFY EAQENHNLIG VANVFLECLF
YDVKLQYAVP IISQQGEVAG RLHIEVMRVT GVVPERVIEG DDSSENSSES GSLEVMDSNG
DVIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCG STVAAPVVDP DVPSPQSKEP
QFTVTFSHCE DYVVNVTEEF LEFISEGALA IEVWGHRCTG NGSSIWEVDS LHATTRTLQD
RWNEVTRRIE MWISILELNE MGEYAAVELH QAKDVNTGGV FQLRQGHSRR VQVTVKPVQH
SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQRDDEDG DDMDSYQEED LNFVRERWSD
ALIKRREYLD EQIKKVSNKK EKTDDDLERE ARLVEQWVGL TEERNAVLVP APGSGIPGAP
ADWTPPAGME THIPVLFLDL NADDLSANEQ LVGPHASGVN SILPKEHGSQ FFYLPIIKHS
DDEVSATASW DSSVHDSVHL NRVTPQNERI YLIVKTTVQL SHPAAMELVL RKRIAANVYN
KQSFTQSLKR RISLKNVFYS CGVTYEIVSN IPKATEEIED RETLALMAAR SENEGTSDGE
TYIEKYTRGV LQVENILSLE RLRQAVTVKE ALSTKARHIR RSLSTPNVHN VSSSRQDLSG
CDEDDKGWSE SHLDMSDCSS SYQDVLCYGT LPRDSPRRIK EACASENPHA LTVSPFKAFS
PQPPKFFKPL MPVKEEHKKK SPLETRPLLS QEDSEEEEHE LETISKKLVS SQPYVPVEFA
DFSVYNAGLE SREWFSSKAD FLNSRVLEKE VSRSPTTSSI TSGYFSHSAS NATLSDMTVP
SSDSTDQLAN QMKDLDASEH SGSSLVHDSR PSSNKELAEP EGDLAKDKIS TVTLKENSAL
VKGSPPSQNS IKKSSKELCR TGSCSGTDSC SSKNNRTPVG FSTREATIEH MSDIVEDHSF
TEFMGVSDGK DFDGISGPLL SSVGDLSSVK RNPPSKTDAK SNADWLQNLD QPEYEAESEQ
LLNSTVNPLC SELTKEAPHG QADPDASHHE YFLRKNHLDV SDGEDGLLTE QVYTVPSWMT
VGEQVCFGNK TGIVRYIGPV DFLTGTWVGV ELNVQMGKHD GTVKGKEYFR CKPQHGIFVR
PGRLLKASTK KCSNTSRPQA ASSLEKRKSS VVPVPSPSFS KAGEAALCHT GDAAASTFSR
KQENRKSWIN
//
