ID F6S7Z9_MACMU Unreviewed; 843 AA.
AC F6S7Z9; G7MPI8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Patched domain containing 4 {ECO:0000313|Ensembl:ENSMMUP00000004962.3};
GN Name=PTCHD4 {ECO:0000313|Ensembl:ENSMMUP00000004962.3,
GN ECO:0000313|VGNC:VGNC:83450};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000004962.3, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000004962.3}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004962.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; F6S7Z9; -.
DR SMR; F6S7Z9; -.
DR PaxDb; 9544-ENSMMUP00000004962; -.
DR Ensembl; ENSMMUT00000005267.3; ENSMMUP00000004962.3; ENSMMUG00000003719.3.
DR VEuPathDB; HostDB:ENSMMUG00000003719; -.
DR VGNC; VGNC:83450; PTCHD4.
DR eggNOG; KOG1934; Eukaryota.
DR GeneTree; ENSGT00940000156827; -.
DR HOGENOM; CLU_002359_4_1_1; -.
DR TreeFam; TF331806; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000003719; Expressed in dorsolateral prefrontal cortex and 4 other cell types or tissues.
DR ExpressionAtlas; F6S7Z9; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR10796:SF15; PATCHED DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 785..807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 230..389
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 843 AA; 96020 MW; 8CCC60BA7796819E CRC64;
MRRPGAPASW IWWRMLRQVL RRGLQSFCHR LGLCVSRHPV FFLTVPAVLT ITFGLSALNR
FQPEGDLERL VAPSHSLAKI ERSLASSLFP LDQSKSQLYS DLHTPGRYGR VILLSPPGDN
ILLQAEGILQ THRAVLEMKD GKNSFIGHQL GGVVEVPNSK DQRVKSARAI QITYYLQTYG
SATQDLIGEK WENEFCKLMR KLQEEHQDLQ LYSLASFSLW RDFHKTSILA RSKVLVSLVL
ILTTATLSSS MKDCLRSKPF LGLLGVLTVC ISIITAAGIF FITDGKYNST LLGIPFFAMG
HGTKGVFELL SGWRRTKENL PFKDRIADAY SDVMVTYTMT SSLYFITFGM GASPFTNIEA
VKVFCQNMCV SILLNYFYIF SFFGSCLVFA GQLEQNRYHS IFCCKIPSAE YLDRKPVWFQ
TVMSDGHQQT SHHETNPYQH HFIQHFLREH YNEWITNIYV KPFVVILYLI YASFSFMGCL
QISDGANIIN LLASDSPSVS YAMVQQKYFS NYSPVIGFYV YEPLEYWNSS VQEDLRRLCS
GFTAVSWVEQ YYQFLKVSNI SANNKSDFIS VLQSAFLKKP EFQHFRNDII FSKAGDESNI
IASRLYLVAR TSRDKQKEVI EVLEKLRPLS LSKSIRFIVF NPSFVFMDHY SLSVTVPVLI
AGFGVLLVLI LTFFLVIHPL GNFWLILSVT SIELGVLGLM TLWNVDMDCI SILCLIYTLN
FAIDHCAPLL YTFVLATEHT RTQCIKSSLQ EHGTAILQNV TSFLIGLVPL LFVPSNLTFT
LFKCLLLTGG CTLLHCFVIL PVFLTFFPPS KKHHKKKKRA KRKEREEIEC IEIQENPDHV
TTV
//
