ID F6SBC7_CIOIN Unreviewed; 614 AA.
AC F6SBC7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Cullin-4A {ECO:0000313|Ensembl:ENSCINP00000002393.3};
GN Name=LOC100175879 {ECO:0000313|Ensembl:ENSCINP00000002393.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000002393.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000002393.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR AlphaFoldDB; F6SBC7; -.
DR STRING; 7719.ENSCINP00000002393; -.
DR Ensembl; ENSCINT00000002393.3; ENSCINP00000002393.3; ENSCING00000001234.3.
DR GeneTree; ENSGT00940000156905; -.
DR HOGENOM; CLU_004747_7_2_1; -.
DR InParanoid; F6SBC7; -.
DR OMA; FWPSYIP; -.
DR TreeFam; TF101153; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 257..487
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 614 AA; 71485 MW; ED26DD4822DD5A4E CRC64;
MIRCIFLVLD RTYVLQNSML PSLWDLGLDL FRENVLSREH VRERCFFGLL NLIKRERSGD
TIDRCLLRNL LSMLNDLHIY HTMFEKRFLH ETEESYSIEG SAKRSSMEVH EYLIHTERRI
SEERDLCLAC MDHSTLKPLT LCVEEQLISK HTEALLSKGL SHLIVENRID DLMRLYKLFS
AVKDGIQSLC THFNKHVKNV ASLIVLDVSN DHTMVQDLLD LKEKLSNIVT KCFSKDLKFV
EALREAFESS INKRQNKPAE LIAKYVDQRM KSGNKEATEV ELDRTLDQIM MLFRFIHGKD
VFEAFYKKDL AKRLLVGKSA SVDAEKSMLS KLKQECGGMF TGKLEGMFND ISHSKELMAQ
YRQHVTTKKE GKVPNIDMSV NILTMGYWPT YPPMEVQLPS YLVKLQDSFK DFYLSKHSGR
KLSFRASLGH CVLKSKFKNG NKELQVSQFQ ALVLLLYNEA TCFSFLQIKS DTQIEDSELR
RTLQSLACGK ARILTKSPKG KDVNDGDNFN LNTEFKHKLI RIKINQIQLK ESVEENTDTT
ERVFQDRQYQ IDAAIVRTMK TRKTLSHQLL LTELYDQLKF PLKATDIKKR IESLIERDYM
ERDKDNTTQY HYMA
//
