ID F6SCW7_MACMU Unreviewed; 1165 AA.
AC F6SCW7; H9FSK7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Tectonin beta-propeller repeat-containing protein 1 {ECO:0000256|ARBA:ARBA00016409};
GN Name=TECPR1 {ECO:0000313|EMBL:AFE77616.1,
GN ECO:0000313|VGNC:VGNC:79348};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000020305.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Ensembl:ENSMMUP00000020305.4, ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000020305.4,
RC ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|EMBL:AFE77616.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE77616.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
RN [3] {ECO:0000313|Ensembl:ENSMMUP00000020305.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000020305.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane
CC {ECO:0000256|ARBA:ARBA00004652}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}.
CC -!- SIMILARITY: Belongs to the TECPR1 family.
CC {ECO:0000256|ARBA:ARBA00005966}.
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DR EMBL; JU333861; AFE77616.1; -; mRNA.
DR STRING; 9544.ENSMMUP00000020305; -.
DR Ensembl; ENSMMUT00000021706.4; ENSMMUP00000020305.4; ENSMMUG00000015479.4.
DR VEuPathDB; HostDB:ENSMMUG00000015479; -.
DR VGNC; VGNC:79348; TECPR1.
DR GeneTree; ENSGT00510000047886; -.
DR HOGENOM; CLU_008303_0_0_1; -.
DR OMA; CPMQISR; -.
DR TreeFam; TF323648; -.
DR Proteomes; UP000006718; Chromosome 3.
DR Bgee; ENSMMUG00000015479; Expressed in cerebellar cortex and 19 other cell types or tissues.
DR ExpressionAtlas; F6SCW7; baseline and differential.
DR GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR GO; GO:1901096; P:regulation of autophagosome maturation; IEA:Ensembl.
DR CDD; cd13300; PH1_TECPR1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR23250; DYSFERLIN-RELATED; 1.
DR PANTHER; PTHR23250:SF1; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF06462; Hyd_WA; 2.
DR Pfam; PF06398; Pex24p; 2.
DR Pfam; PF19193; Tectonin; 2.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM00706; TECPR; 11.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 2: Evidence at transcript level;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 64..125
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 137..170
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT DOMAIN 816..877
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00693"
FT DOMAIN 888..921
FT /note="Peroxin/Ferlin"
FT /evidence="ECO:0000259|SMART:SM00694"
FT REGION 404..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1165 AA; 129407 MW; 0C243B3FE00466EF CRC64;
MPNSVLWAVD LFGRVYTLST AGQYWELCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA
SDVPIRRREE AYENQRWNPV GGFCEKLLLS DRWAWSDVSG LQHRPLDGVA LPSPHWEWES
DWYVDENFGG EPTEKGGWTY AIDFPATYTR DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS
KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD
TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSVVEPPGSE NGVMHVSVGV
NVVWAVTKDQ KVWFRRGVNS HNPCGTSWIE MVGEMLMVNV GMNDQVWGIG CEDRAVYFRQ
GVTPSELSGK TWKAIVVARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV
ERPGPGQPLP AEPLDDSKNP TGSSASGPGA GRTAEDTTED ACPAEGSRAA GPDTHPGPAP
TPAELPWTNI DLKEPKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG
GCVVEACAMP RWFTVQAGLS PSVQTLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR VALEQFTGHD GARDSILFIY YVVHEEKKYA
HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR
KVQGRPSPQA IWSITCKGDI FVSEPSPDLE AHEHPLPCDQ MFWRQIGGHL RMVEANSQGV
VWGIGYDHTA WVYTGGYGGG CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL
PTDRYMWSDA SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PITLRDVSII PESPDAERSG HSIALWAISD
KGDVLCRLGV SALNPAGSSW LHVGTDQPFA SISIGACYQV WAVARDGSAF YRGSVYPSQP
AGDCWYHIPS PPRQRLKQVS VGQTSVYALD ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR
VSVGPLDQVW VIANKVQGSH SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA
TRAPRSSSQE QEPSAPPEAH GPVCC
//