ID F6SFI3_XENTR Unreviewed; 2535 AA.
AC F6SFI3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=PDZ domain-containing 2 {ECO:0000313|Ensembl:ENSXETP00000033990};
DE SubName: Full=PDZ domain-containing protein 2 isoform X1 {ECO:0000313|RefSeq:XP_031750652.1, ECO:0000313|RefSeq:XP_031750654.1};
GN Name=pdzd2 {ECO:0000313|Ensembl:ENSXETP00000033990,
GN ECO:0000313|RefSeq:XP_031750652.1, ECO:0000313|RefSeq:XP_031750654.1,
GN ECO:0000313|RefSeq:XP_031750658.1,
GN ECO:0000313|Xenbase:XB-GENE-6044665};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000033990};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000033990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000033990};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000033990}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031750652.1, ECO:0000313|RefSeq:XP_031750654.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031750652.1,
RC ECO:0000313|RefSeq:XP_031750654.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031750652.1,
RC ECO:0000313|RefSeq:XP_031750654.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_031750652.1; XM_031894792.1.
DR RefSeq; XP_031750654.1; XM_031894794.1.
DR RefSeq; XP_031750658.1; XM_031894798.1.
DR STRING; 8364.ENSXETP00000033990; -.
DR Ensembl; ENSXETT00000033990; ENSXETP00000033990; ENSXETG00000015574.
DR AGR; Xenbase:XB-GENE-6044665; -.
DR Xenbase; XB-GENE-6044665; pdzd2.
DR eggNOG; KOG0792; Eukaryota.
DR HOGENOM; CLU_000714_0_0_1; -.
DR OMA; QEGTMSR; -.
DR TreeFam; TF326303; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000015574; Expressed in 4-cell stage embryo and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 6.
DR Gene3D; 2.30.42.10; -; 7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR11324; IL16-RELATED; 1.
DR PANTHER; PTHR11324:SF16; PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 5.
DR SMART; SM00228; PDZ; 7.
DR SUPFAM; SSF50156; PDZ domain-like; 7.
DR PROSITE; PS50106; PDZ; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 306..391
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 564..650
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 706..780
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1144..1228
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 2321..2405
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 2446..2531
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 185..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1722..1838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2143..2185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 653..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2535 AA; 273953 MW; 1047B658319C85BD CRC64;
MPITQENAAL YLALLHRWLQ DNVGGESEAP EKRLYLAAIR KLTQYIQFNF TLDESASKYS
QGALDMEICT VYLTKGDDDD GDVLGLSFGN IPIFGHGGEK RRGGKKRRVQ NGPVLDVGCI
WVTDLKRQSK AAKCGRMRLR DEVLSLNGQL MVGVDVTGAS YLAEQCWNGG FIYLIMLRRI
KRKAPLPPSH GSKSSASEPK AASSSHPSVR TTQNGKRTRK FGVISRTGKE SKDSEEAVQE
NGHYSPMEVD GSHSADEALG NDGDKQRTSR SSDADVQHGY QFPNGDCSDS RSNDHPARNE
GCCIWKMHML KGADGLGIQI TGGRGSKRSP HGIVVAHVEE GGSADRDGRL KAGDELLMIN
GQSLVGLSHQ EAVALLRSSM GIVQLVVASR ESSNVDFCKY PSTSLPDLVS ASSAQDVGAS
SDDKENEEPY VEEGQDYGTS PSHQAAESET DKFQEKGSSE VPKGVCRSPT LGNSLLKYRS
RSQGSGSRLE SVGEDDELTV ANGDLYRDNG DKISRGGRKH SLPQQLDSVG SRQDYNIVKK
TTRSLSTVQV ESPWRLAQPS IISNIVLMKG QGKGLGFSIV GGQDSARGRM GIFVKTIFSN
GAAAADGRLK EGDEILEVNG ESLQGLTHQE AIHKFKQLKK GVVTLTVRTR LRSPSLTPCP
TPTMMSRSSS PNSNISLGTS MPGSEDGDST SGSRKGPGPK DRIIMEVTLN KEPGVGLGIG
ACCLTLENSS PGIYIHSLAP GSVAKMDGRL SRGDQILEAD SVSLRHAALS EAYAILSECG
PGPVSLIISR HPNPKVSEQE MDEVITRTTH RESKDSFHSM GLHLKSPSPA CKPKHGDGPT
SLSWTMKRFL EPASRQGSVS SEAELSQYFS QDAPSHSSFS DTVATGSSDE EQLRPASGSN
SLDDNSAPPC AANAKECGAK AECCIPASHR NGNIPSPCNK HIVSTRQSSL NSSPQSIRSP
LLRQRRIVSY EDEDGSEDGD ISRKDEGNYK DHLKKNADED SGIVMSTLDV DEEIPDHNLP
VKCASEAGTS LCGSSVESED SSVEHMVDSP FFAIKSFDYS AKADARPCSL ALKEPTEGPI
ENKRSPKLEH KAVTRVKSMM SIEYPSSPKP KAEESCLPSK PTKPLPLVKK PEGSEHSGKC
ITDTVQLFCS EYESVGLDLE IKESPLSVII TGLRPAREGE KDSVGKLAAG DEIISINGIQ
VSEMSYQQTC DFIQCLPSSV TLGVRKPLSA VDRLSHIIMA SGGDQQGPVE QVEILRQENS
QCKGPQHTAD CSTPAKVTIE AGNSLTIQCL EAGNDSTVTN IDDFINELDF SGAPSCDFAK
DSNTTEEMEA CVASGQGNRV DAETEEAKTE LCSSITNFDE STSQSENILA FSVLDSLSME
KKFAVDKSCL SSYSRNFSSL TEEDFSLSDQ ILSSSLDLPI SMYVTAEDSD SESFLDSTSD
MISSLQNQSC MSELQTATDS EEEQIEICCD IKKGDSGAHQ FYDVHQLYPA ATLSETPKDL
PDERCGGNTL PGFGHYTSVD RVTVENIVNS GHPDASPTMS LLNNDSQELP CRSEISLNDY
SALQVQDPMT LGVKDNSTDV HNVGLVPLSE GNVYRCHLGP LDSGENMSAV EETIDSHVIP
SCTIVDPSED EKCVTRSSME PEVCPQEASC ANTNEGPITN CTVSTSNVQV KRETLPEGTT
KKSPATRNCN LDMYKPNVPL SKLHTDIKTT LKSSLDILNT QVSKPGPKLK GLSIKSKNKE
QAQNHPAKAD DFRKLSPQPS PKLLAKRASM ADGSTAARDR AVRSPVMTKK PEHKTGLSVQ
SVDSKASANV SANSSTCSSK NDKMSPFSRR TGKCANDKSK DEGFSLRVNS SECPNKTITS
SDSGTKELIE DITAERVPQQ MATEGPETHD IRRTFIEVKL SSALPHALTS ATRRQDGSDK
ANILTNDHFA NVYMSPRINN KSIVCKPVTR TYSMPAHLPI FMDDEGTQTK GQNHCLISQG
SVDCVLEKYL HAGNNSPAVA QNQLKSKLPT QDGQVSNEKY VSRSEIMRSI RRNYYYELNW
CHDPLSSLTV KQRIKSFENL AHFDKTVMKV IDMNHSPFSS KPPICRRSSG SVPSEGSLHD
ASRYLRRSLS SCCDSHSEVT LAAPIETTPP SVALAVIEKS ASDNITQTPV NEESRTEKKE
SSPPAAQIRK NKTSSSHIRP SLSRSKIREL RALSMPDLDK LCTDDFTVEP KAPQFKTELE
IIPARLCDLP GQNMEPASSN LSNTGLMGCS LSGTATDLDE SRPDGTLSRK SWAISLEQLM
VSTQDQQNLQ AVLTSVSSRS DIISLIQEIK TQSEKREGVF FVVLNKEEGT GLGFSIAGGI
DLEQKSVTVH RVFAKAVASQ DTMIEKGDGI LSINGCSLQG AAHGYALNAL HGAKPHRQAV
VVIQKERDGE KLSRLDASRG RHTTSGKDVS MTALAGGSVD LTDTMCVELN KTSAGLGFSL
DGGKASIYGD RPLFIKRIFK GGAAEQAGKI QAGDEIIAIG GKYLTGLMHY DAWNIIKAVP
EGPVQLLIRK HRTAV
//
