ID F6SK62_XENTR Unreviewed; 455 AA.
AC F6SK62; A0A6I8T097;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Paired box 6 {ECO:0000313|Ensembl:ENSXETP00000017931};
DE SubName: Full=Paired box protein Pax-6 isoform X2 {ECO:0000313|RefSeq:XP_031755866.1};
GN Name=pax6 {ECO:0000313|Ensembl:ENSXETP00000017931,
GN ECO:0000313|RefSeq:XP_031755866.1,
GN ECO:0000313|Xenbase:XB-GENE-484088};
GN Synonyms=an2 {ECO:0000313|RefSeq:XP_031755866.1}, d11s812e
GN {ECO:0000313|RefSeq:XP_031755866.1}, mgda
GN {ECO:0000313|RefSeq:XP_031755866.1}, pax-6
GN {ECO:0000313|RefSeq:XP_031755866.1}, pax6-a
GN {ECO:0000313|RefSeq:XP_031755866.1}, pax6-b
GN {ECO:0000313|RefSeq:XP_031755866.1}, wagr
GN {ECO:0000313|RefSeq:XP_031755866.1}, XLPAX6
GN {ECO:0000313|RefSeq:XP_031755866.1}, xpax6
GN {ECO:0000313|RefSeq:XP_031755866.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000017931};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000017931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000017931};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000017931}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031755866.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031755866.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031755866.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR RefSeq; XP_031755866.1; XM_031900006.1.
DR STRING; 8364.ENSXETP00000017931; -.
DR PaxDb; 8364-ENSXETP00000003877; -.
DR Ensembl; ENSXETT00000017931; ENSXETP00000017931; ENSXETG00000008175.
DR Ensembl; ENSXETT00000091449; ENSXETP00000099479; ENSXETG00000008175.
DR AGR; Xenbase:XB-GENE-484088; -.
DR Xenbase; XB-GENE-484088; pax6.
DR eggNOG; KOG0849; Eukaryota.
DR HOGENOM; CLU_019281_1_0_1; -.
DR TreeFam; TF320146; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000008175; Expressed in eyeball of camera-type eye and 26 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636:SF41; PAIRED BOX PROTEIN PAX-6; 1.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 35..161
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT DOMAIN 241..301
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 243..302
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 193..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 49908 MW; 364442191014F437 CRC64;
MLGITQALGR EAEKLSRIPS INHVGPGGDS EMQNSHSGVN QLGGVFVNGR PLPDSTRQKI
VELAHSGARP CDISRILQVS NGCVSKILGR YYETGSIRPR AIGGSKPRVA TPEVVSKIAQ
YKRECPSIFA WEIRDRLLSE GVCTNDNIPS VSSINRVLRN LASEKQQMGA DGMYDKLRML
NGQTGTWGTR PGWYPGTSVP GQPAQDGCQP QEGGGGGENT NSISSNGEDS DEAQMRLQLK
RKLQRNRTSF TQEQIEALEK EFERTHYPDV FARERLAAKI DLPEARIQVW FSNRRAKWRR
EEKLRNQRRQ ASNTPSHIPI SSSFSTSVYQ PIPQPTTPVS SFTSGSMLGR TDTALTNSYS
ALPPMPSFTM GNNLPMQPPV PSQTSSYSCM LPTSPSVNGR SYDTYTPPHM QTHMNSQPMG
TSGTASTGLI SPGVSVPVQV PGSEPDMSQY WPRLQ
//
