ID F6SLX0_XENTR Unreviewed; 534 AA.
AC F6SLX0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Myocyte enhancer factor 2D {ECO:0000313|Ensembl:ENSXETP00000043962};
GN Name=mef2d {ECO:0000313|Ensembl:ENSXETP00000043962};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000043962};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000043962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000043962};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000043962}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; F6SLX0; -.
DR Ensembl; ENSXETT00000043962; ENSXETP00000043962; ENSXETG00000020378.
DR AGR; Xenbase:XB-GENE-483879; -.
DR Xenbase; XB-GENE-483879; mef2d.
DR InParanoid; F6SLX0; -.
DR Bgee; ENSXETG00000020378; Expressed in skeletal muscle tissue and 16 other cell types or tissues.
DR ExpressionAtlas; F6SLX0; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00265; MADS_MEF2_like; 1.
DR Gene3D; 3.40.1810.10; Transcription factor, MADS-box; 1.
DR InterPro; IPR022102; HJURP_C.
DR InterPro; IPR033896; MADS_MEF2-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR PANTHER; PTHR11945; MADS BOX PROTEIN; 1.
DR PANTHER; PTHR11945:SF23; MYOCYTE-SPECIFIC ENHANCER FACTOR 2D; 1.
DR Pfam; PF12347; HJURP_C; 2.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SRF-like; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..61
FT /note="MADS-box"
FT /evidence="ECO:0000259|PROSITE:PS50066"
FT REGION 218..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 58277 MW; 898E87849090964C CRC64;
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST
DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGDDSIDQS PLMEDKYRKA
SEDLDILFKR YGALNKKHRE YESPDADEVF ALTPQTEEKY KKIDEEFDKM MQSYRLASAV
PAPNFAMPVT VPVTNQNALQ FSNPGGSLVT QSLMTSSLTD PRLLSPPQPA LQRNTVSPGL
PQRPASAGAM LGGELNNSNG TCPSPVGNGY ISARASPGLI PVSNGNSLGK VIPAKSPPPP
NQNSQLGANS RKPDLRVITS QGGKGLMHHL SAQRLGGVSQ AAHSLTTPVV SVATPSLLSH
HGLPFSAMPT AYNTDYQLTS ADLSSLSTFS SPSSLSLGNV TAWQQQQQQQ HHHQAQQLIP
VSLSNLVSSG QLPHTATLTV NTNPNISIKK EPPSPNRERS TGTPLSSFPH QSRHEVTGRS
PVDSLSSNAS SFEGNDREDV RGDYTSSLGL LRPSGDTESE SQSVKRMRLD AWVT
//
