ID F6SM01_MONDO Unreviewed; 576 AA.
AC F6SM01;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=RUN and FYVE domain containing 2 {ECO:0000313|Ensembl:ENSMODP00000021575.5};
GN Name=RUFY2 {ECO:0000313|Ensembl:ENSMODP00000021575.5};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000021575.5, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000021575.5, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000021575.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007478319.2; XM_007478257.2.
DR AlphaFoldDB; F6SM01; -.
DR Ensembl; ENSMODT00000021951.5; ENSMODP00000021575.5; ENSMODG00000017293.5.
DR GeneID; 100015003; -.
DR CTD; 55680; -.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000155595; -.
DR HOGENOM; CLU_014576_3_1_1; -.
DR OrthoDB; 5385125at2759; -.
DR TreeFam; TF323904; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000017293; Expressed in cerebellum and 20 other cell types or tissues.
DR CDD; cd17695; RUN_RUFY2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047332; RUN_RUFY2.
DR PANTHER; PTHR45956:SF3; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..576
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023837340"
FT DOMAIN 176..308
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 38..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 366..492
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 47..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 64983 MW; 4F5CD504C3F21225 CRC64;
MHSSRPLVFV SIFCSPAPLS GARGWGVCIS SHSPSLRPLG AETFSSRPPS GGRSCLLQSQ
PPSNSPSLES SSPCGPTPRS GSLRSSDRQG ALHPPSCHAS RGTLLRWRPW LWTGRRDQRL
PEPEAELLSP SPPARPSAAM AVKDPTAVER ANLLNMAKLS IKGLIESALS FGRTLDSDYP
PLQQFFVVME HCLKHGLKVR KSFLSYNKTI WGPLELVEKL YPEAEEIAAS VRDLPGLKTP
LGRARAWLRL ALMQKKMADY LRCLIIQRDL LSEFYEYHAL MMEEEGAVIV GLLVGLNVID
ANLCVKGEDL DSQVGVIDFS MYLKNEEDIG SKERNVQIAA ILDQKNYVEE LNRQLNSTVS
SLHSRVDSLE KSNTRLIEEL AIAKNNIIKL QEENHQLRSE NKLILMKTQQ HLEVTKVDVE
TELQTYKQSR QGLDEMYNEA RRQLREEAQL RQDVENELMV QVSMKHEIEL AMKLLEKDIH
EKQDTLIGLR QQLEDVKAIN IEMYQKLQGS EEGMKEKNEI IGRLEDKTNK ITAAMKQLEQ
SDKDLLTQTR TIAMSFVKCA SSDTQPQYKL VKDISF
//
