ID F6SMC6_HORSE Unreviewed; 470 AA.
AC F6SMC6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN Name=ALDH3A1 {ECO:0000313|Ensembl:ENSECAP00000008456.2,
GN ECO:0000313|VGNC:VGNC:15234};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008456.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000008456.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008456.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000008456.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008456.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate;
CC Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00000589};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00036150};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC ECO:0000256|RuleBase:RU003345}.
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DR AlphaFoldDB; F6SMC6; -.
DR SMR; F6SMC6; -.
DR STRING; 9796.ENSECAP00000008456; -.
DR PaxDb; 9796-ENSECAP00000008456; -.
DR Ensembl; ENSECAT00000010897.3; ENSECAP00000008456.2; ENSECAG00000009407.3.
DR VGNC; VGNC:15234; ALDH3A1.
DR GeneTree; ENSGT00940000162101; -.
DR HOGENOM; CLU_005391_3_0_1; -.
DR InParanoid; F6SMC6; -.
DR OMA; RHGKRWM; -.
DR OrthoDB; 606537at2759; -.
DR TreeFam; TF314264; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000009407; Expressed in blood and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; IBA:GO_Central.
DR CDD; cd07132; ALDH_F3AB; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43570:SF15; ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING; 1.
DR Pfam; PF00171; Aldedh; 1.
DR PIRSF; PIRSF036492; ALDH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 16..442
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 227
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT ECO:0000256|PROSITE-ProRule:PRU10007"
FT ACT_SITE 261
FT /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ SEQUENCE 470 AA; 52302 MW; 46B77EB7C0A69C21 CRC64;
MLIPGAPATR RGCIKGTMSK ISEVVQRARA AFNSGKTRPL QFRIQQLEGL RRMIKEREKD
IAGALTADLH KNEWNAYYEE VVYVLEEIEY MIKKLPEWAA DEPMERTAQT QLDESYIHWE
PLGVVLIISA WNNPFNLAIQ PMVGAIAAGN AVVIKPSELS ENMANLLATI IPQYVDKDLY
AVINGGISET TEVLKERFDH ILYTGSTGVG KIIMMAAAKH LTPITLELGG KNPCYVDKDC
DLDIACRRIA WGKFMNSGQT CVGPDYILCD PSIQNQIVEK LKKSLKEFYG EDAKKSRDYG
RIINSHHFQR VMGLMEGQKV AYGGTGDAAT RYIAPTILTD VDPQSQVMQE EIFGPILPIV
CVRSLEEAIE FISQREKPLA LYVFSLNDKV IKKMIAETSS GGVTANDVFV HVTLHSLPYG
GVGNSGMGSY HGKKSFETFS HRRSCLVRPL LNDESLKARY PPSLVKMAGH
//