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Database: UniProt
Entry: F6SMC6_HORSE
LinkDB: F6SMC6_HORSE
Original site: F6SMC6_HORSE 
ID   F6SMC6_HORSE            Unreviewed;       470 AA.
AC   F6SMC6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   Name=ALDH3A1 {ECO:0000313|Ensembl:ENSECAP00000008456.2,
GN   ECO:0000313|VGNC:VGNC:15234};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008456.2, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000008456.2, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008456.2,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000008456.2}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008456.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate;
CC         Xref=Rhea:RHEA:44100, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17935, ChEBI:CHEBI:25646, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; Evidence={ECO:0000256|ARBA:ARBA00000589};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC         Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00036150};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC       ECO:0000256|RuleBase:RU003345}.
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DR   AlphaFoldDB; F6SMC6; -.
DR   SMR; F6SMC6; -.
DR   STRING; 9796.ENSECAP00000008456; -.
DR   PaxDb; 9796-ENSECAP00000008456; -.
DR   Ensembl; ENSECAT00000010897.3; ENSECAP00000008456.2; ENSECAG00000009407.3.
DR   VGNC; VGNC:15234; ALDH3A1.
DR   GeneTree; ENSGT00940000162101; -.
DR   HOGENOM; CLU_005391_3_0_1; -.
DR   InParanoid; F6SMC6; -.
DR   OMA; RHGKRWM; -.
DR   OrthoDB; 606537at2759; -.
DR   TreeFam; TF314264; -.
DR   Proteomes; UP000002281; Chromosome 11.
DR   Bgee; ENSECAG00000009407; Expressed in blood and 10 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IBA:GO_Central.
DR   CDD; cd07132; ALDH_F3AB; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF15; ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN          16..442
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        227
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        261
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ   SEQUENCE   470 AA;  52302 MW;  46B77EB7C0A69C21 CRC64;
     MLIPGAPATR RGCIKGTMSK ISEVVQRARA AFNSGKTRPL QFRIQQLEGL RRMIKEREKD
     IAGALTADLH KNEWNAYYEE VVYVLEEIEY MIKKLPEWAA DEPMERTAQT QLDESYIHWE
     PLGVVLIISA WNNPFNLAIQ PMVGAIAAGN AVVIKPSELS ENMANLLATI IPQYVDKDLY
     AVINGGISET TEVLKERFDH ILYTGSTGVG KIIMMAAAKH LTPITLELGG KNPCYVDKDC
     DLDIACRRIA WGKFMNSGQT CVGPDYILCD PSIQNQIVEK LKKSLKEFYG EDAKKSRDYG
     RIINSHHFQR VMGLMEGQKV AYGGTGDAAT RYIAPTILTD VDPQSQVMQE EIFGPILPIV
     CVRSLEEAIE FISQREKPLA LYVFSLNDKV IKKMIAETSS GGVTANDVFV HVTLHSLPYG
     GVGNSGMGSY HGKKSFETFS HRRSCLVRPL LNDESLKARY PPSLVKMAGH
//
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