ID F6STR1_MONDO Unreviewed; 1312 AA.
AC F6STR1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Contactin associated protein like 4 {ECO:0000313|Ensembl:ENSMODP00000000784.3};
GN Name=CNTNAP4 {ECO:0000313|Ensembl:ENSMODP00000000784.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000784.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000000784.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000000784.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_007498011.1; XM_007497949.2.
DR STRING; 13616.ENSMODP00000000784; -.
DR Ensembl; ENSMODT00000000802.4; ENSMODP00000000784.3; ENSMODG00000000655.4.
DR GeneID; 100015389; -.
DR KEGG; mdo:100015389; -.
DR CTD; 85445; -.
DR eggNOG; KOG3516; Eukaryota.
DR GeneTree; ENSGT00940000157674; -.
DR HOGENOM; CLU_003504_1_0_1; -.
DR InParanoid; F6STR1; -.
DR OMA; LSTQNWS; -.
DR OrthoDB; 4255614at2759; -.
DR TreeFam; TF321823; -.
DR Proteomes; UP000002280; Chromosome 6.
DR Bgee; ENSMODG00000000655; Expressed in spinal cord and 7 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00057; FA58C; 1.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.60.120.200; -; 4.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR001791; Laminin_G.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR15036:SF40; CONTACTIN-ASSOCIATED PROTEIN-LIKE 4; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00282; LamG; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS01286; FA58C_2; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1312
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003341829"
FT TRANSMEM 1245..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..181
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 187..368
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 375..551
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 553..590
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 589..640
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT DOMAIN 797..962
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 963..1001
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1013..1206
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 935..962
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1312 AA; 146592 MW; D0EC674C07D17A6B CRC64;
MNMNMDSVTE AFLKLLFLLS IQNWSPVVAG NAYNCDDQLV SALPQSSFSC SSELSSSHSP
GFARLNRRDG AGGWTPLMSN KYQWLQVDLS ERMEITAIAT QGGYGSSDWV TSYLLMFSDS
GRNWKQYRQE ESIWGFSGNT NADSVVYYKL QHSIKARFLR FIPLAWNPNG RIGMRIEVYG
CSYRSEVVDF DGNSFLLYRF DEKSISPLKD IISFKFKTME SDGILLHRKG QNGDYITLEL
IRGKLFLFIN SGDVKLHSTN SLINITTGSL LDDQHWHSVL IEHFNKQVNF TVDKHTQHFH
AKGEFNYLDL NYELSFGGIL AAGKSVSFSH KNFHGCFENL YCNGVNIINL AKRQKPQIYI
MGNVSFSCSQ PQTVPVTFLG SGSYLALHGS SGQDEISVSF QFRTWNKMGL LLSSNFHQHT
GSLLLYLHNG KIRLNIFKQG KQQSDVTTGV ELNNGQWHSI FLSAKRNHLS IMIDNDVTSV
PHFVLPMQIY SGDIYYFGGC PNTSSDSECK NPFGGFQGCM RHISISNKVV DLILVQQSIF
GNFSDLQIDL CGLIDRCLPN YCEHGGECSQ SWNSFYCNCT NTGYMGATCH SSIYEQSCEA
YKHRGNTSGF YYIDSDGSGP LRPFLVYCNM TDTAWTIVQH NSTDFTRVKS SNRENPHTVF
FKYTANTEQL QATINHAEHC EQELAYHCKK SRLLNKRDGI PLSWWVGRTN ETQTYWGGSL
PDVQKCTCGL EGNCIDSQYY CNCDADRNEW ANDTGFLSYK EHLPVTQIVI TDTDRPNSEA
AYKLGPLLCR GDRSFWNSAS FNTETSYLHF PTFHGELSAD VSFFFKTTAS SGVFLENLGI
KDFIRIELHS PAEVIFSFDV GNGPFEVVVQ SPTHLNDNQW HYVRAERNIK EASLQVDQFP
TKSQPAPVDG HILLQLNSQL FVGGTASRQK GFLGCIRSLQ LNGIALDLEE RAKITPGVDP
GCPGHCSSYG NLCHNGGKCK EKHSGFSCDC SFSAYSGPFC LNEISAYFGS GSSVAYNFQE
YYTLSKNSSS HAASFHGDMT LIREMITFSF RTTRTPSLLL YVGSFYKEYL SVILAKNGSL
QIRYKLDSHQ EADVFNSNFK NMADGQLHHV KINREEGVLF VEVNQNAREQ VTLSSGIEFN
AIKSLVLGKI LENSDVDQET MKASSQGFTG CLSSVQFNHI APLKAALYHA SSAPVTVKGH
VAESNCGALA GAESPLSETT HSFADHSGPI DEGEPLANAI RSDSAIIGGV IAVVIFILLC
ITAIAVRIYQ QKSLYKKNEA KRAENEDCAE TALKSELTVQ NRVNENQKEY FF
//
