ID F6SW62_MACMU Unreviewed; 1024 AA.
AC F6SW62;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=WW and C2 domain containing 1 {ECO:0000313|Ensembl:ENSMMUP00000009784.4};
GN Name=WWC1 {ECO:0000313|Ensembl:ENSMMUP00000009784.4,
GN ECO:0000313|VGNC:VGNC:79809};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000009784.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000009784.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000009784.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6SW62; -.
DR SMR; F6SW62; -.
DR STRING; 9544.ENSMMUP00000009784; -.
DR PaxDb; 9544-ENSMMUP00000009784; -.
DR Ensembl; ENSMMUT00000010425.4; ENSMMUP00000009784.4; ENSMMUG00000007457.4.
DR VEuPathDB; HostDB:ENSMMUG00000007457; -.
DR VGNC; VGNC:79809; WWC1.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00410000025556; -.
DR HOGENOM; CLU_005420_0_0_1; -.
DR InParanoid; F6SW62; -.
DR OMA; QVTVVSM; -.
DR TreeFam; TF324040; -.
DR Proteomes; UP000006718; Chromosome 6.
DR Bgee; ENSMMUG00000007457; Expressed in adult mammalian kidney and 21 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0046621; P:negative regulation of organ growth; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0035330; P:regulation of hippo signaling; IBA:GO_Central.
DR CDD; cd08680; C2_Kibra; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF00168; C2; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 564..687
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 335..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..40
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 70..97
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 200..234
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 266..335
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 914..976
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 429..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..779
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1024 AA; 114455 MW; 0361F6392DD9B3E3 CRC64;
MLKDYLVVAQ EALSAQKEIY QVKQQRLELA QQEYQQLHAV WEHKLGSQVS LVSGSSSSSK
YDPEILKAEI ATAKSRVNKL KREMVHLQHE LQFKERGFQT LKKIDKKMSD AQGSYKLDEA
QAVLRETKAI KKAITCGEKE KQDLIKSLAM LKDGFRTDRG SHSDLWSSSS SLESSSFPLP
KQYLDVSSQT DISGSFSINS NNQLAEKVRL RLRYEEAKRR IANLKIQLAK LDSEAWPGVL
DSERDRLILI NEKEELLKEM RFISPRKWTQ GEVEQLEMAR KRLEKDLQAA RDTQSKALTE
RLKLNSKRNQ LVRELEEATR QVATLHSQLK SLSSSMQSLS SGSSPGSLTS SRGSLVASSL
DSSTSASFTD LYYDPFEQLD SELQSKVEFL LLEGATGFRP SGCITTIHED EVAKTQKAEG
GGRLQALRSL SGTPKSMTSL SPRSSLSSPS PPCSPLMADP LLAGDAFLNS LELEDPELSA
TLCELNLGNS TQERYRLEEP GTEGKQLGQA VNTAQGCGLK VACVSAAVSD ESVAGDSGVY
EASVQRLGAS EAAAFDSDES EALGAARVQI ALKYDEKNKQ FAILIIQLSN LSALLQQQDQ
KVNIRVAVLP CSESTTCLFR TRPLDASDTL VFNEVFWVSM SYPALHQKTL RVDVCTTDRS
HLEECLGGAQ ISLAEVCRSG ERSTRWYNLL SYKYLKKQSR ELKPVGVTAP APGPASTDAV
SALLEQTAVE LEKRQEGRSG TQTLEDSWRY EETSENEAVA EEEEEEVEEE EEEEDVFTEK
ASPDMDGYPA LKVDKETNTE TPAPSPTVVR PKDRRVGTPS PGPFLRGSTI IRSKTFSPGP
QSQYVCRLNR SDSDSSTLSK KPPFVRNSLE RRSVRMKRPS PPPQPSSVKS LRSERLIRTS
LDLELDLQAT RTWHSQLTQE ISVLKELKEQ LEQAKSHGEK ELPQWLREDE RFRLLLRMLE
KRMDQAEHKG ELQTDKMMRA AAKDVHRLRG QSCKEPPEVQ SFREKMAFFT RPRMNIPALS
ADDV
//
