ID F6T045_CALJA Unreviewed; 354 AA.
AC F6T045;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Homer protein homolog 1 {ECO:0000313|EMBL:JAB39712.1};
DE SubName: Full=Homer scaffold protein 1 {ECO:0000313|Ensembl:ENSCJAP00000084942.1};
GN Name=HOMER1 {ECO:0000313|EMBL:JAB39712.1,
GN ECO:0000313|Ensembl:ENSCJAP00000084942.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB39712.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000084942.1, ECO:0000313|Proteomes:UP000008225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB39712.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:JAB51515.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB31284.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB20823.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB39712.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000084942.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMS01002313; JAB20823.1; -; mRNA.
DR EMBL; GAMR01002648; JAB31284.1; -; mRNA.
DR EMBL; GAMQ01002139; JAB39712.1; -; mRNA.
DR EMBL; GAMP01001240; JAB51515.1; -; mRNA.
DR RefSeq; XP_002744875.1; XM_002744829.3.
DR STRING; 9483.ENSCJAP00000052946; -.
DR Ensembl; ENSCJAT00000148075.1; ENSCJAP00000084942.1; ENSCJAG00000019722.4.
DR GeneID; 100392638; -.
DR KEGG; cjc:100392638; -.
DR CTD; 9456; -.
DR eggNOG; ENOG502QR3K; Eukaryota.
DR GeneTree; ENSGT00940000156354; -.
DR OrthoDB; 5490527at2759; -.
DR TreeFam; TF325627; -.
DR Proteomes; UP000008225; Chromosome 2.
DR Bgee; ENSCJAG00000019722; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF3; HOMER PROTEIN HOMOLOG 1; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50229; WH1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..110
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 114..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..332
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 122..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 40279 MW; 13510F049D3D3F78 CRC64;
MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST
ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK
MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDVTQNS EPRAEPTQNA LPFSHSSAIS
KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN
AVHTHKSELN QTIQELEETL KEKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD
LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LECS
//
