ID   F6T067_CALJA            Unreviewed;      1167 AA.
AC   F6T067;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Rho GTPase-activating protein 20 isoform 2 {ECO:0000313|EMBL:JAB30981.1};
GN   Name=ARHGAP20 {ECO:0000313|EMBL:JAB30981.1};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB30981.1};
RN   [1] {ECO:0000313|EMBL:JAB30981.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB30981.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT   sequences.";
RL   Gigascience 3:14-14(2014).
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DR   EMBL; GAMR01002951; JAB30981.1; -; mRNA.
DR   RefSeq; XP_009004994.1; XM_009006746.1.
DR   AlphaFoldDB; F6T067; -.
DR   GeneID; 100406381; -.
DR   CTD; 57569; -.
DR   OrthoDB; 2964977at2759; -.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd13319; PH_RARhoGAP; 1.
DR   CDD; cd17115; RA_RHG20; 1.
DR   CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR   InterPro; IPR047887; ARHGAP20_PH.
DR   InterPro; IPR047888; ARHGAP20_RA.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23179:SF28; RHO GTPASE-ACTIVATING PROTEIN 20; 1.
DR   PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          171..272
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          342..528
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          743..767
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          891..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1028..1063
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1116..1153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..759
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        906..987
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1119..1148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1167 AA;  130303 MW;  405BA88ED01B4901 CRC64;
     MSARERQPAL KKKMKTLAER RRSAPSLILD KALQKRPTTR ESPSASVDTC TFLSSFVCSN
     RTLLIDGRAE LKRGLQRQER HLFLFNDLFV VAKIKYNNNF KIKNKIKLTD MWTANCVDEV
     GEGNTNAMKS FVLGWPIVNF VATFSSSEQK DKWLSLLQRY INLEKEKDYP KSIPLKIFAK
     DIGNCAYSKT ITVMNSDTVN EVINMALPML GITGSERDYQ LWVNSGKEEA PYPLIGHEYP
     YGIKMSHLRD TALLTPGSKD STTPFNLQEP FLMEQLPREM QCQFILKPSR LAAAQPLSDS
     GHKTFKRRRS IINWAFWRGS STHLDNLPTS PTSPMPGELF GISLPNICVN DNLPKPVLDM
     LFFLNQKGPL TKGIFRQSAN VKSCRELKEK LNSGVEVHLD CESIFVIASV LKDFLRNIPG
     SIFSSDLYDH WVSVLDQGND EEKINTVQRL LDQLPRANVV LLKYLFGVLH NIEQHSSSNQ
     MTAFNLAVCV APSILWPPTS SSPELENEFT KKVSLLIQFL IENCCRIFGE EITSLFGEVS
     VRCDARENAS DISCFQLNDS SYDSLENELN EDVDAPCSDL VKKLNQGSRS MDSVLTLSDY
     DLDQPEVEGL LTLSDFDLTH SKDEDVQMKQ PLEAKPVNVL VYTKIPLRDH ARAPSTCIPS
     YLSTAAANAA KSLRRHRRCS EPSIDYLDSK LSYLREFYQK KLRKSSCDAI LSQKDEDYLK
     QNQPLQEEGK TCFKQSLVTG TDASKKNATT QNTKKKSLSG SEGNHVKLFP KSKPVAISVA
     SYSPVSSQDH SKNQCFHMDT SAYSPPHTAD ALKGPRTHRR CSEPNIEDQN RKLTYLRGIY
     SKKQHKTSCE AGVLHGEEDY LKRHKSLQME GQKLINQSLV MGIEVGKSST TNQNTEKVLP
     PRLNLCPRTS YSSLSSPGTS PSGSSVSSQD SAFSQISEHS VFTPTETSSP IDCTFQAQRK
     QEELSPDLSS SSHVSGMPSP SSGQACSRMA YTKKDTMEWH SQMHSVTLHP STWLRNGVAS
     LKNWSLKKKA KAARPEETKI GSPKGPLEPP SHASSVSEAN SLQEKQKDLL LRAAEGLAPL
     QSAQMCSSSP CQDSERHCSS PFSLVESRLK LCMKSHEEVE PGSQSSSGSL PWERASASSW
     TLEEVTSPDS GPTVVCDIED RYLTKDI
//