ID   F6T1S5_CALJA            Unreviewed;       423 AA.
AC   F6T1S5;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=TTL family tubulin polyglutamylase complex subunit L1 {ECO:0000313|Ensembl:ENSCJAP00000045939.1};
GN   Name=TTLL1 {ECO:0000313|Ensembl:ENSCJAP00000045939.1};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000045939.1, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000045939.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000045939.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000256|ARBA:ARBA00004120}.
CC   -!- SIMILARITY: Belongs to the tubulin polyglutamylase family.
CC       {ECO:0000256|ARBA:ARBA00006118}.
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DR   RefSeq; XP_008978046.1; XM_008979798.2.
DR   RefSeq; XP_008978057.1; XM_008979809.2.
DR   RefSeq; XP_017819477.1; XM_017963988.1.
DR   AlphaFoldDB; F6T1S5; -.
DR   STRING; 9483.ENSCJAP00000045939; -.
DR   Ensembl; ENSCJAT00000060688.4; ENSCJAP00000045939.1; ENSCJAG00000009758.5.
DR   GeneID; 100401316; -.
DR   CTD; 25809; -.
DR   GeneTree; ENSGT00940000156720; -.
DR   InParanoid; F6T1S5; -.
DR   OMA; DWNFYWS; -.
DR   OrthoDB; 7265at2759; -.
DR   TreeFam; TF313087; -.
DR   Proteomes; UP000008225; Chromosome 1.
DR   Bgee; ENSCJAG00000009758; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IEA:Ensembl.
DR   GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR   GO; GO:0002395; P:immune response in nasopharyngeal-associated lymphoid tissue; IEA:Ensembl.
DR   GO; GO:0120197; P:mucociliary clearance; IEA:Ensembl.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0120222; P:regulation of blastocyst development; IEA:Ensembl.
DR   GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   InterPro; IPR004344; TTL/TTLL_fam.
DR   PANTHER; PTHR12241:SF31; POLYGLUTAMYLASE COMPLEX SUBUNIT TTLL1; 1.
DR   PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR   Pfam; PF03133; TTL; 1.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   PROSITE; PS51221; TTL; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT   REGION          391..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  49107 MW;  221FC7E79E0C75E3 CRC64;
     MAGKVKWVTD IEKSVLINNF EKRGWVQVTE NEDWNFYWMS VQTIRNVFSV ETGYRLSDDQ
     IVNHFPNHYE LTRKDLMVKN IKRYRKELEK EGSPLAEKDE NGKYLYLDFV PVTYMLPADY
     NLFVEEFRKS PSSTWIMKPC GKAQGKGIFL INKLSQIKKW SRDSKTSSFV SQSNKEAYVI
     SLYINNPLLI GGRKFDLRLY VLVSTYRPLR CYMYKLGFCR FCTVKYTPST SELDNMFVHL
     TNVAIQKHGD DYNHIHGGKW MVSNLRLYLE STRGKEVTSK LFDEIHWIIV QSLKAVAPVM
     NNDKHCFECY GYDIIIDDKL KPWLIEVNAS PSLTSSTAND RILKYNLIND TLNIVVPNGE
     IPDCKWNKSP PKEVLGNYEI LYDEELAQGD GADRELRSRQ GQSQGPRAGR SRDSGRTVLT
     TWK
//