ID F6T2B5_XENTR Unreviewed; 897 AA.
AC F6T2B5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Exosome component 10 {ECO:0000313|Ensembl:ENSXETP00000013853, ECO:0000313|RefSeq:XP_012821790.1};
GN Name=exosc10 {ECO:0000313|Ensembl:ENSXETP00000013853,
GN ECO:0000313|RefSeq:XP_012821790.1,
GN ECO:0000313|Xenbase:XB-GENE-946594};
GN Synonyms=pm-scl {ECO:0000313|RefSeq:XP_012821790.1}, pm/scl-100
GN {ECO:0000313|RefSeq:XP_012821790.1}, pmscl
GN {ECO:0000313|RefSeq:XP_012821790.1}, pmscl2
GN {ECO:0000313|RefSeq:XP_012821790.1}, rrp6
GN {ECO:0000313|RefSeq:XP_012821790.1}, rrp6p
GN {ECO:0000313|RefSeq:XP_012821790.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000013853};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000013853}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000013853};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000013853}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012821790.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012821790.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012821790.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR RefSeq; XP_012821790.1; XM_012966336.3.
DR Ensembl; ENSXETT00000013853; ENSXETP00000013853; ENSXETG00000006318.
DR GeneID; 407941; -.
DR AGR; Xenbase:XB-GENE-946594; -.
DR CTD; 5394; -.
DR Xenbase; XB-GENE-946594; exosc10.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_1_1_1; -.
DR OMA; NIMRPQM; -.
DR OrthoDB; 2880475at2759; -.
DR TreeFam; TF105991; -.
DR Reactome; R-XTR-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000006318; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 506..586
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 103043 MW; AC7F920B98EE3F3B CRC64;
MAAPGGGMQK MENSVDIRED QDLSRDNSEP IPGFSDTDAF VKFALGTVVS ATKASTGLPQ
GGDEYDFYRS FPGFRDFCES QGEHLLHCMS QVMQYHGLRS HIRDRSRVTL LEDKFDLLVD
ANDVILEKVG ILLDEASGLN RNQQPILPAG LQPPKTIVSS WNRKTSDLSK KGKSETFRLL
HAKNILRPQL KFKEKIDNSN TPFVSKLFVK PNAQKPLPEV LRNRLERQQR QEDLDVPPAL
ADFIHQQRMK ISEEDMFCHP YQYELDHFVP LESSMEKPDI QPVLSLQDVP CKFVMKLEDL
VALNEKLLQC AEFAVDLEHH SYRSFLGLTC LMQISTRTED YIIDVLELRS NMYILNESFT
NPSIIKVLHG ADSDIEWLQK DFGLYIVNMF DTHQAARILN LGRHSLDHLL RLYCNVESDK
RYQLADWRIR PLPEEMIEYA RADTHYLLFI YDKMRTALLG AANKQQNLLQ LVWQKSRDIC
LKKFTKSIFT EDSYLELYQK QKKHLNTQQL TAFRLLFAWR DKIARQEDES TGYVLPNHML
LKITEELPKE PQGIIACCSP VPPLVRQQIN ELSLLIHQAR ETPLLKSEIS SAKKKGPMAN
PERMENLLFG PHDTSLQLAD NNHLYSGTVL CVFPGLQNSE GSLFTDEEPV VPVPMNPAFI
LSRASITIFN GFEDEEVVPS KNWPVSQQKA RNILESFENP FKMFLPPEDR RAHVSQAAKL
DPNTKMFEIS KQWKLVSLAQ QEKEAKAKED ARRQKREEKA AREQAKRDFK SSVENQKSVR
EQAKDEESSK KRERVSSEPG SETMKSDKKR IKNSEETQEP VSQAPFTPFD YSKSDFKMFA
GSSNVKSQSE FDPNKQTHKG KQKNISTRKG HQLMGNKSMS FVATKSDRGF QHSWPKR
//
