ID F6T4Z0_HORSE Unreviewed; 518 AA.
AC F6T4Z0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=DEAD-box helicase 5 {ECO:0000313|Ensembl:ENSECAP00000020563.3};
GN Name=DDX5 {ECO:0000313|VGNC:VGNC:17098};
GN Synonyms=POLG2 {ECO:0000313|Ensembl:ENSECAP00000020563.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020563.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020563.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020563.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020563.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020563.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6T4Z0; -.
DR STRING; 9796.ENSECAP00000020563; -.
DR PaxDb; 9796-ENSECAP00000020563; -.
DR Ensembl; ENSECAT00000024735.3; ENSECAP00000020563.3; ENSECAG00000011132.4.
DR CTD; 11232; -.
DR VGNC; VGNC:17098; DDX5.
DR GeneTree; ENSGT00940000154705; -.
DR HOGENOM; CLU_055833_0_0_1; -.
DR InParanoid; F6T4Z0; -.
DR OMA; WGQEVLE; -.
DR OrthoDB; 2901447at2759; -.
DR TreeFam; TF103005; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000023052; Expressed in inner cell mass and 23 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
DR Gene3D; 3.40.50.800; Anticodon-binding domain; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004154; Anticodon-bd.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR027031; Gly-tRNA_synthase/POLG2.
DR PANTHER; PTHR10745:SF8; DNA POLYMERASE SUBUNIT GAMMA-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR10745; GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2; 1.
DR Pfam; PF03129; HGTP_anticodon; 1.
DR SUPFAM; SSF52954; Class II aaRS ABD-related; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 428..510
FT /note="Anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF03129"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 518 AA; 57952 MW; 19176670EE5C0583 CRC64;
MSRVGGARRP RQEEGRASVG GSCAHALPSR LRSGRSGSAW WRLVEISRLG GDCPLNPEAM
RSGAAVRAGR KVCRVLLSGF GGRLDGGQAE RLTEGSSSLG GPLSSHEELP RGSEPREAPE
SGSGGSEALV EMCQRRYFLS GTERQLSRES LLSGCHPGFG PLGIELRKNL AAEWWSSVVA
FREQVFPVDA LHHEPGPALP RDSAFRLVSA ETLREILQDK EMSKEQLVAF LENLLKTSGK
LRESLLHGAL EHYVNCLDLV NKRLPYGLAQ IGVCFHPVSD TKQTPDGVKR IGEKTEASLV
WFTSARTASQ WLDFWLRHRL LWWRKFAMSP SNFSSSDCQD EEGRKGNKLY YNFPWGKEPI
ETLWNLGDHE LLHMYPGNGS QLYGRDGRKS VVPSVLSING DLDRGMLAYL YDSFQLTENS
FTRKKNLHRK VCQGLFNELL ESGISVWPGY LETVQSSLEQ LYSKYDEMSI LFTVLITEAT
LENGLIHLRS RDTTMKEMMH ISKVKDFLTK YISSAKNV
//
