ID F6TB92_XENTR Unreviewed; 373 AA.
AC F6TB92;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Guanine nucleotide-binding protein (G protein), alpha 15 (Gq class) {ECO:0000313|Ensembl:ENSXETP00000019100};
DE SubName: Full=Guanine nucleotide-binding protein subunit alpha-11 {ECO:0000313|RefSeq:XP_002934852.2};
GN Name=gna15 {ECO:0000313|Ensembl:ENSXETP00000019100,
GN ECO:0000313|RefSeq:XP_002934852.2,
GN ECO:0000313|Xenbase:XB-GENE-1011753};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019100};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000019100}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019100};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000019100}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002934852.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002934852.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002934852.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(q) subfamily.
CC {ECO:0000256|ARBA:ARBA00007976}.
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DR RefSeq; XP_002934852.2; XM_002934806.4.
DR STRING; 8364.ENSXETP00000019100; -.
DR Ensembl; ENSXETT00000019100; ENSXETP00000019100; ENSXETG00000008714.
DR KEGG; xtr:100496529; -.
DR AGR; Xenbase:XB-GENE-1011753; -.
DR Xenbase; XB-GENE-1011753; gna15.
DR eggNOG; KOG0085; Eukaryota.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OMA; LEENCHD; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Bgee; ENSXETG00000008714; Expressed in testis.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000654; Gprotein_alpha_Q.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF217; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-15; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00442; GPROTEINAQ.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..373
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197236"
SQ SEQUENCE 373 AA; 43794 MW; 211BB158D9A55E12 CRC64;
MPWWCCCCFF PPCLSEEETT ALTVNREIER ILKLQKERSR GEIKVLLLGT GESGKSTFIK
QMRIIHGAGF SEQERKFYAR LVHQNIVTCA QSLVGAMETL QVPYSIENNQ INGRKISELD
AFRIQAIEEP YVKAIKNLWS DTGIQRCYER RREFQLLDST NYYLSNLERL TQDMYQPTDE
DILRIRMPTT GINEYSFPVE NMNLRMVDVG GQKSERRKWI HSFENVSALI YLASLSEYDQ
RLEENCHDNR MKESLALFRN ILELPWFQET PIILFLNKTD LLEEKIAFSD LANYFHRFKG
PCRDAEAAKQ FILDNYKEIF NKIRKQDASG KDDLKHKVYH HFTCATDTDN IRKVFNNVKE
AVLVKYLMDF GIL
//
