ID F6TBS4_XENTR Unreviewed; 1090 AA.
AC F6TBS4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 8b isoform X1 {ECO:0000313|RefSeq:XP_012825655.2, ECO:0000313|RefSeq:XP_031748422.1};
DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 8 {ECO:0000313|Ensembl:ENSXETP00000007105};
GN Name=trpm8b {ECO:0000313|RefSeq:XP_012825655.2,
GN ECO:0000313|RefSeq:XP_031748422.1,
GN ECO:0000313|Xenbase:XB-GENE-12442826};
GN Synonyms=trpm8 {ECO:0000313|Ensembl:ENSXETP00000007105};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000007105};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000007105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000007105};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000007105}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012825655.2, ECO:0000313|RefSeq:XP_031748422.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012825655.2,
RC ECO:0000313|RefSeq:XP_031748422.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012825655.2,
RC ECO:0000313|RefSeq:XP_031748422.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_012825655.2; XM_012970201.3.
DR RefSeq; XP_031748422.1; XM_031892562.1.
DR Ensembl; ENSXETT00000007105; ENSXETP00000007105; ENSXETG00000003271.
DR AGR; Xenbase:XB-GENE-998832; -.
DR Xenbase; XB-GENE-998832; trpm8.
DR Xenbase; XB-GENE-12442826; trpm8b.
DR eggNOG; KOG3614; Eukaryota.
DR HOGENOM; CLU_001390_0_0_1; -.
DR OMA; FREDMEN; -.
DR OrthoDB; 201873at2759; -.
DR TreeFam; TF314204; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Bgee; ENSXETG00000003271; Expressed in endocrine gland and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF9; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_012825655.2,
KW ECO:0000313|RefSeq:XP_031748422.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 681..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..971
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 992..1012
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..366
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 727..975
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 1090 AA; 125580 MW; 1B9A7A08D54F7249 CRC64;
MSGMNYQHDV EGSQNLYSSI ELSPAGQQSG DVERYNIKDI KKRECIVFTQ DPSSQESLCK
CGYLKRQHTE GVQTNQNDRW NYTRHTKELS TDAYGEIQFE TFGRRAKYIR LSRDTAPAIL
YKLMTSYWQL KTPNLIISVT GGARNFSLKP RIRKIIRRLI YIAQSKGAWI FTGGTHNGLT
KYIGEVVRDN TISQSSEGKV AAIGIAAWGM ISNRDSLIRS PDDEGKYIAH YVMDEKKEDG
LYCLDNNHTH FILVDNGSHK HPTIEAELRA SLEGCISELT APDSDYSGKI PIVCFVHSGG
KETLKAINRA IKSKIPCVVV EGSGQIADVI ASLVETEGTS VPSTIIKEKM LHFLKYTVSR
LTEDELEAWI QWIKEIMESP NLLTVIKIDE AGDETVSDAI SAALYKAYST RELDKGNWNA
QLKLLLEWNQ LELANNELFA NGQHWKTADL EDAMFTALVK DRPEFVRLLL ENGLDLDKFL
SSEVLRQLFS EHFSTHAFKS LEMADKSYNP LLTFVWRMVL VYQPSNKEKW NSSDYKIQNI
SSLIKRHPTQ VLFIWAILQN KRELSTVIWE QTKACTLAAL GASKLLKHLA KVNKDIKTAQ
ESEEMAHEYE TRAVDLFTEC YSNDKKLAGM LLVHSCEAWG KSNCLDMAVA ANDQQFIAQP
GVQNFLSKQW YGAISRDTKT WKILLSLFIF PLISCGFITF RNISNRKRSR LWKYCDFFTS
PFVVFSWTVI FYIGFLFLFA YVLLMDFQPI PTGLEIVVYL LVFILLCIEI RQMIISRAEY
SRDCWNIMDC MAILYFIVGV LFRLQNSNPS ALYVGRVILC LDYIIFTLRL IQIFTISQNL
GPKIIMLQRM FVDVFFFLFL FAVWIVAFGV ANQGILRLNE HRWEWIFRSV IYQPYLAMFG
GPFSDVDEAT YDFDKCTITG NESKPLCVEV DSENNPRFPE WITIPLVSVY MLSTNILLVN
LLIAMFGYTV GSVQDNNEQV WKFQRYFLVQ EYCSRITIPF PFVIFGYIYL IMRNLFSWCY
KKQEPPPLPC CFNKEDNKTL AWEAVMKENY LVKKISETQN NREMEHRFKQ LEGKLNELHS
LVMDLTVRIK
//
