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Database: UniProt
Entry: F6TDZ1_HORSE
LinkDB: F6TDZ1_HORSE
Original site: F6TDZ1_HORSE 
ID   F6TDZ1_HORSE            Unreviewed;      4840 AA.
AC   F6TDZ1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   13-FEB-2019, entry version 49.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSECAP00000013172};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSECAP00000013172,
GN   ECO:0000313|VGNC:VGNC:22644};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013172, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013172, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013172,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013172}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013172};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSECAT00000016310; ENSECAP00000013172; ENSECAG00000013267.
DR   VGNC; VGNC:22644; RYR3.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000002281; Chromosome 1.
DR   Bgee; ENSECAG00000013267; Expressed in 2 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4153   4177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4381   4401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4449   4468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4580   4598       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4641   4662       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4721   4744       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       83    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      145    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      198    252       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      258    316       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      326    383       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      568    779       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      995   1191       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1237   1449       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3888   3923       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      442    462       {ECO:0000256|SAM:Coils}.
FT   COILED     3199   3219       {ECO:0000256|SAM:Coils}.
FT   COILED     3374   3394       {ECO:0000256|SAM:Coils}.
FT   COILED     3568   3588       {ECO:0000256|SAM:Coils}.
FT   COILED     4303   4323       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4840 AA;  548979 MW;  4292DAD63F6A6F77 CRC64;
     EDEVVLQCIA NVHKEQRKFC LAAEGLGNRL CFLEPTSEAK YVPPDLCVCN FVLEQSLSVR
     ALQEMLANTG ENGGEGAAQG GGHRTLLYGH AILLRHSFSG MYLTCLTTSR SQTDKLAFDV
     GLREHATGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVF SERYLHLSIS NGNIQVDASF
     MQTLWNVHPT CSGSSIEEGY LLGGHVVRLF HGHDECLTIP STDQNDSQHR RVFYEAGGAG
     TRARSLWRVE PLRISWSGSN IRWGQAFRLR HLTTGHYLAL TEDQGLILQD RGKSDTKSTA
     FSFRASKEIK EKLDSSHKRD IEGMGVPEIK YGDSVCFVQH VSSGLWVTYK AQDAKTSRLG
     PLKRKVILHQ EGHMDDGLTL QRCQQEESQA ARIIRNTTAL FSQFVSGNNR TTAPVTLPIE
     EVLQTLQDLI AYFQPPEEEM QHEDKQNKLR SLKNRQNLFK EEGMLALVLN CIDRLNIYNS
     VAHFAGIARE ESGMAWKEIL NLLYKLLAAL IRGNRNNCAQ FSNNLDWLIS KLDRLESSSG
     ILEVLHCILI ESPEALNLIA EGHIKSIISL LDKHGRNHKV LDVLCSLCLC NGVAVRANQN
     LICDNLLPRR NLLLQTRLIN DVTSIRPNIF LGVAEGSAQY KKWYFELIID QVDPFLTAEP
     THLRVGWASS SGYAPYPGGG EGWGGNGVGD DLYSYGFDGL HLWSGRIPRA VASINQHLLK
     SDDVVSCCLD LGVPSISFRI NGQPVQGMFE NFNTDGLFFP VVSFSAGVKV RFLMGGRHGE
     FKFLPPTGYA PCYEALLPKE KMRLEPVKEY KRDAEGVRDL LGTTQFLSQA SFIPCPIDTS
     QVVLPPHLEK IRDRLAENIH ELWGMNKIEL GWTFGKIRDD NKRQHPCLVE FSKLPETEKN
     YNLQMSTETL KTLLALGCHI AHVNPAAEED LKKVKLPKNY MMSNGYKPAP LDLSDVKLLP
     PQEILVDKLA ENAHNVWAKD RIKQGWTYGI QQDLKNKRNP RLVPYALLDE RTKKSNRDSL
     REAVRTFVGY GYNIEPSDQE LADPAVEKVS IDKIRFFRVE RSYAVRSGKW YFEFEVVTGG
     DMRVGWARPG CRPDVELGAD DQAFVFEGSR GQRWHQGSGY FGRTWQPGDV VGCMINLDDA
     SMIFTLNGEL LITNKGSELA FADYEIENGF VPICSLGLSQ IGRMNLGMDA STFKFYTMCG
     LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV PKDHPHIEVV RIDGTMDSPP CLKVTHKTFG
     TQNSNANMIY CRLSMPVECH ASFSHSPCLD SDAFQKRKQM QEILSHTTTQ CYYTIRIFAG
     QDPSCVWVGW VTPDYHLYSE KFDLNKNCTV TVTLGDERGR VHESVKRSNC YMVWGGDIVA
     TSQRSSRSNV DLEIGCLVDL AMGMLSFSAN GRELGTCYQV EPNTKVFPAV FLQPTSTALF
     QFELGKLKNA MPLSAAIFKS EEKNPVPQCP PRLDIQTIQP VLWSRMPNSF LKVETERVSE
     RHGWVVQCLE PLQMMALHIP EENRCVDILE LCEQEDLMLF HYHTLRLYSA VCALGNSRVA
     YALCSHVDLS QLFYAIDNKY LPGLLRSGFY DLLISIHLAS AKERKQMMKN EYIIPITSST
     GKIRLYPDES KRHGLPGVGL RTCLKPGFRF STPCFVVTSE EHQKQSPEIP LEILKTKALS
     MLTEAVQCSG AHIRDPVGGS VEFQFVPVLK LIGTLLVMGV FDDDSVRQIL LLIDPSVFGE
     HSGEMEEGAE KEEVTQVEEK AVEAGEKASK EAPVKGLLQT RLPESVKLQM CELLSYLCDC
     ELQHRVEAIV AFGDIYVSKL QANQKFRYNE LMQALNMSAA LTARKTREFR SPPQEQINML
     LNFQLGENCP CPEEIREELY DFHEDLLIHC GVPLEEEEEE EEDTSWTGKL RALVYKIKGP
     PKPEKELPTE EEERCPTTLK ELISQTMIRW AQEDQIQDAE LVRMMFNLLR RQYDSIGELL
     QALRKTYTIS QASVSDTINL LAALGQIRCL LSVRMGKEEE LLMINGLGEI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL GAEKSQIAFP KMVASCCRFL CYFCRISRQN QKAMFEHLSY
     LLENSSVGLA SPSMRGFTPL DVAASSVMDN NELALGLEEP DLEKVVTYLA GCGLQSCPML
     LAKGYPDVGW NPIEGERYLS FLRFAVFVNS ESVEENASVV VKLLIRRPEC FGPALRGEGG
     NGLLAAMQGA IKISENPALD LPSQGYKREV TEDAEDDEIV HMGNAIMSFY SALIDLLGRC
     APEMHLIQTG KGEAIRIRSI LRSLVPTEDL VGIISIPLKL PSLNKDGSVS EPDMAANFCP
     DHKAPMVLFL DRVYGIKDQT FLLHLLEVGF LPDLRASASL DTVSLSTTEA ALALNRYLCS
     AVLPLLTRCA PLFAGTEHYT SLIDSTLQTI YRLSKGRSLT KAQRDTIEEC LLAICNHLRP
     SMLQQLLRRL VFDVPQLNEY CKMPLKLLTN HYEQCWKYYC LPSGWGSYGL AVEEELHLTE
     KLFWGIFDSL SHKKYDQDLF RMALPCLSAI AGALPPDYLD TRISATLEKQ VSVDADGNFD
     PKPINTVNFS LPEKLEYIVT KYAEHSHDKW ACDKSLNRWK YGISLDENVK THPLIRPFTL
     TEKEKEIYRW PARESLKTML AVGWTIERTK EGEALVQQRE NEKLRSVSQA SQGNSYSPAP
     LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG GSHPLLVPYD TLTAKEKFRD
     REKAQDLFKF LQVNGIVVSR GMKDMELDAS SMEKRFAYKF LKKILKYVDS AQEFIAHLEA
     IVSSGKTEKS PHDQEIKFFA KVLLPLVDQY FTNHRLYFLS SPLKPLSSSG YASHKEKEMV
     ASLFCKLAAL VRHRISLFGN DSTTMVSCLH ILAQTLDTRT VMKSGSELVK AGLRAFFENA
     AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI LTSIFEHVAQ HQFGVDLLLG
     DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA AIPVAFLEPT LNRYNPLSVF
     NTKTPRERSI LGMPDTVEEM CPDVPQLEGL MKEINDLAES GARYTEMPHV IEVILPMLCN
     YLSYWWERGP EHLPPSTGPW CTKVTSEHLS VTLGNILKII NNNLGIDEAS WMKRIAVYAQ
     PIISKARPGL LRSHFLPTLE KLKKKAVKTV QEEEQLKADS KGDTQEAELL ILDEFAVLCR
     DLYAFYPMLI RYVDNNRSNW LKSPDAYSDQ LFRMVAEIFI LWCKSHNFKR EEQNFVIQNE
     INNLAFLTGD SKSKMSKSGG QDQERKKTKR RGDLYSIQTS LIVAALKKML PIGLNMCTPG
     DQELISLAKS RYSYKDTDEE VKEHLRNNLH LQEKSDDPAV KWQLNLYKDV LKSEEPSNPE
     KTVERVQRIS AAVFHLEQVE QPLRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPHKINN
     FFLSTFQRVW LEKVNEKTQY DRLIPILMKS PKVEEEEEEE TEKQPDPLHQ IILHFSRNAL
     TERSKLEDDP LYTSYSSMMA KSCQSGEEEE EEEDKEKTFE EKEMEKQKTL YQQARLHERG
     AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ KMLDYLKEKK DAGFFQSLSG
     LMQSCSVLDL NAFERQNKAE GLGMVTEEGT REKILQNDEF TRDLFRFLQL LCEGHNSDFQ
     NFLRTQMGNT TTVNVIISTV DYLLRLQESI SDFYWYYSGK DIIDESGQHN FSKALAVTKQ
     IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSSQI ELLKELLDLL
     QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSTNVEMILK FFDMFLKLKD LTSSDTFKEY
     DPDGKGIISK KEFQKAMEGQ KQYIQSEIDF LLSCAEADEN DMFNYIDFVD RFHEPAKDIG
     FNVAVLLTNL SEHMPNDSRL KSLLDPAESV LNYFEPYLGR IEIMGGAKKI ERVYFEISES
     SRTQWEKPQV KESKRQFIFD VVNEGGEQEK MELFVNFCED TIFEMQLASQ ISESDSADRP
     EEEEQAEEDS SYMLEIEGEE EDDRSFESVS AFAMACASVR RNVANFLKRA TLKNLRKQYR
     KVKKMTVKEL VKVFFSFFWT LFVGLFQLFF TILGGIFQIL WNTVFGGGLV EGAKNIRVTK
     ILGDMPDPTQ FGIHDDALEA ERAEVTEPGI ATELVYFVKG EKGDADIMSD LFGYHSKKES
     GLKHGPEVGL GDLSEIIGKD EPPTLESAVQ KKRKAQAAEM KAAHEAEGKV ESEKADMEDG
     EKEDTAKEEV QAEALWAEAT KKKKRRCGQK VEKPEAFMAN FFKGLEIYQT KLLHYLARNF
     YNLRFLALFV AFAINFILLF YKVTEEPLEE ETEDVANLWN SFNDEEEEEA MVFFVLQEST
     GYMAPTLRAL AIIHTIISLV CVVGYYCLKV PLVVFKREKE IARKLEFDGL YITEQPSEDD
     IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN KYGDLYGAER IAELLGLDKS ALDFSPVEET
     KAEAASLVSW LSSIDMKYHI WKLGVVFTDN SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA
     MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD
     DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD PYEMYRIVFD ITFFFFVIVI LLAIIQGLII
     DAFGELRDQQ EQVREDMETK CFICGIGNDY FDTTPHGFET HTLQEHNLAN YLFFLMYLIN
     KDETEHTGQE SYVWKMYQER CWDFFPAGDC FRKQYEDQLG
//
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