ID F6TGC8_CIOIN Unreviewed; 1312 AA.
AC F6TGC8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=C-type mannose receptor 2 {ECO:0000313|Ensembl:ENSCINP00000004176.3};
GN Name=LOC100176419 {ECO:0000313|Ensembl:ENSCINP00000004176.3};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000004176.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000004176.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSCINT00000004176.3; ENSCINP00000004176.3; ENSCING00000002050.3.
DR GeneTree; ENSGT01050000244842; -.
DR HOGENOM; CLU_002069_2_0_1; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00037; CLECT; 7.
DR CDD; cd00062; FN2; 1.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 8.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR22803:SF124; C-TYPE LECTIN DOMAIN FAMILY 19 MEMBER A-RELATED; 1.
DR PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR Pfam; PF00040; fn2; 1.
DR Pfam; PF00059; Lectin_C; 8.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00034; CLECT; 8.
DR SMART; SM00059; FN2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 8.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 6.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 8.
DR PROSITE; PS00023; FN2_1; 1.
DR PROSITE; PS51092; FN2_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1278..1299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..56
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 70..187
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 215..329
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 361..490
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 517..646
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 675..792
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 821..953
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 983..1110
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1139..1258
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DISULFID 13..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 27..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 1312 AA; 148343 MW; 83DD897AF24C085B CRC64;
IYTIGGNAGG DPCLFPFTFM GVSYSDCTTA GRSDNQKWCA TTSNYAKDFI WGICPQPVRG
CGDFWVEGQF GEYCYQFNFQ SSQTWVQARD ACRQQNADLL SITSPKEQAW IAAGRINVVT
TVMWLGMSDI TVEGNWAWSD GYPLVYLNWR AGQPNSYGGN EDCGAIITRN GLWGDTPCSR
HLSFICKKRE NVAVKPYKKQ LTTATLYCES GWKSIGGRCF RLGCTIPSVW FDAQTSCKKV
GADVARIGSK AELDEIIVWM EATRSLKIST YDDLWIGLND IDHEMHFEWD DGVTPTFTYW
GKDQPVDIQG DRDCVKMSLA SGRWDDVSCY SYPSNSTCIH SGSNVTLPTP DKGCPVGWVG
FEATCYKFVH QQTNWTDGYR LCQRRFGNIS RMIVPHNRFE QTFLTTQSHH YDITVTFHLN
ILALSQPTTG WHFFDTDFDD VKQSKKIIFT NWERNQPSYR VGMCVSMGAG SHAGLWKVGN
CKDQRRVVCT QPRQGFTTAP PPTTPIPLPC PDGWQAIKTK CFKVFNEIYR VRRKTWSQAR
DFCRMLGGDQ GNADLASIHS DEEISLIKTK AIGNFVHGGY LWIGLNKRGQ DGHHSWRWSD
NSAVDYMNWG SNGEKPSVNE NCVEYQANIN FWRGSTCNGL RNWICQIDRG ASVVDMNSVT
TQAPQTCGDA SWLYFNGSCY YFSNRKRMAY YDARKYCQSM SSDLTSVENI EEQNYLHQQI
QRLILSEWWI GLDMNNRDNS FRWADGKPFT FHSWRPNEPN YVNKQETCVY IYQSDGTWND
YNCGKKISFI CKKSNNTVPT PTTPVPDYNP KGFCPGGWWE YRGYCIKIFG ENATDRLNWT
DARDDCMSLG GNLLSIVNAQ QQAFITSRLF NVSVGAMWVG LNDMFGEGRF LWRDGTPYWY
SNWKHGEPNS PGYRNNGAQV SCVCACVCVL TDEYSVGKWE DAVCSEKSSY ICEMHKSVSL
GFVKPPATIP MGGGLCAKGW VYWNKECWLL TKQAMTWDMA QKKCSTNGAS LATISDEFTQ
SLAFSLLSDP TENPDTAVPG GVQAWLGLKR QATSPGTSYA WITGWPVSFT NWGDHEPSDS
NGTTSGCIAM DGQGFWYDVQ CNYTLPALCR KTDKKPPANV TNYEGHCPVS LLQSNWVPFQ
SNCYFFQPKT EMATWYQADF DCRKMGAYPA SIHSKEEAMF IIRRSGAYRR GHWIGLYRQL
DDDTFAWSDG TPMDFMYWAE GQPSKGNGFA KELCTELTLP EGRWNDNSCN KIGFTVCKKP
RVIDSKPKPI PGSNSNEVGL AVGLSCVILI LGIMLVLVYN HRRGETKTKY SF
//
