ID F6TGH5_HORSE Unreviewed; 623 AA.
AC F6TGH5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Fas associated factor 1 {ECO:0000313|Ensembl:ENSECAP00000006721.3};
GN Name=FAF1 {ECO:0000313|Ensembl:ENSECAP00000006721.3,
GN ECO:0000313|VGNC:VGNC:17775};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006721.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006721.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006721.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006721.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006721.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6TGH5; -.
DR Ensembl; ENSECAT00000008913.3; ENSECAP00000006721.3; ENSECAG00000008495.4.
DR VGNC; VGNC:17775; FAF1.
DR GeneTree; ENSGT00940000154831; -.
DR HOGENOM; CLU_028119_0_0_1; -.
DR TreeFam; TF314172; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000008495; Expressed in gluteus medius and 23 other cell types or tissues.
DR ExpressionAtlas; F6TGH5; baseline.
DR CDD; cd02990; UAS_FAF1; 1.
DR CDD; cd14413; UBA_FAF1; 1.
DR CDD; cd17129; Ubl1_FAF1; 1.
DR CDD; cd17056; Ubl_FAF1; 1.
DR CDD; cd01771; UBX_UBXN3A; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR033043; FAF1-like_UBX.
DR InterPro; IPR049483; FAF1_2-like_UAS.
DR InterPro; IPR044541; FAF1_UBA.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR006577; UAS.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR PANTHER; PTHR23322:SF56; FAS-ASSOCIATED FACTOR 1; 1.
DR PANTHER; PTHR23322; FAS-ASSOCIATED PROTEIN; 1.
DR Pfam; PF21021; FAF1; 1.
DR Pfam; PF14555; UBA_4; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00594; UAS; 1.
DR SMART; SM00166; UBX; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 3.
DR PROSITE; PS50033; UBX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 542..619
FT /note="UBX"
FT /evidence="ECO:0000259|PROSITE:PS50033"
FT REGION 56..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 70718 MW; 1C31353118544C13 CRC64;
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSDYGGET
IPGPAFDPAN RPAPAPPSSS SSAFRPVMPS RQIVERQPRM LDFRVEYRDR NVDVVLEDSC
TVGEIKQILE NELQIPVSKM LLKGWKTGDV EDSTVLKSLH LPKNNSLYVL TPDLPPPSSS
SHAGALQESL NQNFMLIITH REVQREYNLN FSGSSTIQEV KRNVYDLTSI PVRHQLWEGW
PTTATDDSMC LAESGLSYPC HRLTVGRRSS PAQTREQSEE QSTDVHMVSD SDGDDFEDAS
EFGVDDGEVF GMASSALRKS PMMPENAENE EEALLQFAAE FSSRYGDCHP VFFIGSLEAA
FQEAFYVKAR DRKLLAIYLH HDESVLTNVF CSQMLCAESI VSYLSQNFIT WAWDLTKDAN
RARFLTMCNR HFGSVVAQTI RTQKTDQFPL FLIIMGKRSS NEVLNVIQGN TTVDELMMRL
MAAMEIFTAQ QQEDIKDERE AHEREMAEQF RLEQIRKEQE EEREAIRLSL EQALPPEPKE
ENAEPVSKLR IRTPSGEFLE RRFLASNKLQ IVFDFVASKG FPWDEFKLLS TFPRRDVTQL
DPNKSLLEVK LFPQETLFLE AKE
//
