ID F6TGK2_XENTR Unreviewed; 1044 AA.
AC F6TGK2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=BUB1B, mitotic checkpoint serine/threonine kinase {ECO:0000313|Ensembl:ENSXETP00000000565};
DE SubName: Full=Mitotic checkpoint serine/threonine-protein kinase BUB1 beta {ECO:0000313|RefSeq:XP_031747062.1};
GN Name=bub1b {ECO:0000313|Ensembl:ENSXETP00000000565,
GN ECO:0000313|RefSeq:XP_031747062.1,
GN ECO:0000313|Xenbase:XB-GENE-1010857};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000000565};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000000565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000000565};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000000565}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031747062.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031747062.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031747062.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_031747062.1; XM_031891202.1.
DR STRING; 8364.ENSXETP00000000565; -.
DR PaxDb; 8364-ENSXETP00000039039; -.
DR Ensembl; ENSXETT00000000565; ENSXETP00000000565; ENSXETG00000000287.
DR KEGG; xtr:100125106; -.
DR AGR; Xenbase:XB-GENE-1010857; -.
DR Xenbase; XB-GENE-1010857; bub1b.
DR eggNOG; KOG1166; Eukaryota.
DR HOGENOM; CLU_010890_0_0_1; -.
DR OMA; QPWMAPP; -.
DR TreeFam; TF105456; -.
DR Proteomes; UP000008143; Chromosome 8.
DR Bgee; ENSXETG00000000287; Expressed in 4-cell stage embryo and 9 other cell types or tissues.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR PANTHER; PTHR14030:SF25; MITOTIC CHECKPOINT SERINE_THREONINE-PROTEIN KINASE BUB1 BETA; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000313|RefSeq:XP_031747062.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transferase {ECO:0000313|RefSeq:XP_031747062.1}.
FT DOMAIN 49..213
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 666..1044
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 197..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 405..439
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 204..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1044 AA; 118016 MW; 7F02038380564D31 CRC64;
MAQAGDEWEL SKENVQPLRQ GRVMSTLQEV LSQQESASHT AIQQQKQAFE LELRFYSGDD
PLDVWDRYIK WAEQAFPQGG KESNLCPLLE RAVKIFHEEQ RYYDDLRYLS ICLKFANFCS
EPLDLYSYLH SQRIGVSHAL LYITWAEQFE ARGNFKKADS IFQQGMQHKA EPLEKLEIHH
RQFQARVSRQ ILQGISEGPE AEEPEVPEPQ RSSLADLKSR GKNKVKAPIN RVGDSIKPRP
HGLSVQAAPT QQIPSRSRFA VFDENAASAA PELPSLTPQQ WTAPPPARSK ENEQKAGQWN
SGRPSRNSHQ AAAASEPPQT LPSFMPYVDE SAQQQTVTPC KINPAVTSVL SSRKPGKEED
PLQRVQNNSQ GKEEKVMYCK DKVYAGVEEF SLEEIRAEIY LAKIRKKRED DLQEIALRRQ
EMERQIQEME KQLKGSCIES EEIVSDQPVQ NVEPIIAPCN SNTNESLCAS QQAPVMEFPH
CFEMADAAPT LPRMETLPVF NETGNKPSLP GLSPALSCDL PFTIFDESAE AAPSMTDQKR
MAAPVRRPLA AVPKSIVKSQ ESQLTDTLDG TEPLNEEAIV CGSGKNKSLF PDPEDTCDFV
RAAHLASTPF HRARDQSGEC LQSDSLDLER LPLREKTPVC EESYRQELCI KKLSPILEAS
QEDTRTSVSS VSSISSTTSM FTSRPIPEKL ELATQITGVY ESEPTTEELP QAEELAELHR
QLLESLPELL VSPEIQHEVG TMPDMKEQGE VVLGCETYGL KNEVILHPNS KLFMGAPVDW
DMGDMKAFAL KVDYQPLPWD FYVTMQLKER LGDLFETFFI EQTNCFLYQN GCISLYKDIN
RFSIQEILLD SEEHIKEVIV LVTYNLLSLV EKLHSVEIVH GDLRPETLLL DDKIFDLSSS
LELKGLFKLV DFSHSVDLKL YPIMSSLRGF PIAQTESGQQ FLSPQSSPYQ VDLLGIADLV
HLMIFRKPLQ LHQENSVWMI CKEVPRLRGG NLWNKFFTKI LNAEGPSTRV LGELKGEMMG
QFDSCFQDKL CNYFIQLEMR LNPL
//
