ID F6TJ35_HORSE Unreviewed; 866 AA.
AC F6TJ35;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Transient receptor potential cation channel subfamily C member 3 {ECO:0000313|Ensembl:ENSECAP00000020783.3};
GN Name=TRPC3 {ECO:0000313|Ensembl:ENSECAP00000020783.3,
GN ECO:0000313|VGNC:VGNC:24550};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020783.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020783.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020783.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020783.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020783.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; F6TJ35; -.
DR Ensembl; ENSECAT00000024993.4; ENSECAP00000020783.3; ENSECAG00000023168.4.
DR VGNC; VGNC:24550; TRPC3.
DR GeneTree; ENSGT01060000248588; -.
DR HOGENOM; CLU_005716_4_2_1; -.
DR OMA; FYLIMRI; -.
DR TreeFam; TF313147; -.
DR Proteomes; UP000002281; Chromosome 2.
DR Bgee; ENSECAG00000023168; Expressed in cerebellum and 10 other cell types or tissues.
DR ExpressionAtlas; F6TJ35; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005459; TRPC3_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF8; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01644; TRPCHANNEL3.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 348..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..258
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 866 AA; 99383 MW; ABE8BBB63BDAF050 CRC64;
MSMEGSPSLR RKTVMREKGR RQAVRGPAFM FNDRGTSLTA EEERFLDAAE YGNIPVVRKM
LEESKTLNVN CVDYMGQNAL QLAVGNEHLE VTELLLKKEN LARIGDALLL AISKGYVRIV
EAILNHPGFA ASKRLTLSPC EQELQDDDFY AYDEDGTRFS PDITPIILAA HCQKYEVVHM
LLMKGARIER PHDYFCKCGD CMEKQRHDSF SHSRSRINAY KGLASPAYLS LSSEDPVLTA
LELSNELAKL ANIEKEFKND YRKLSMQCKD FVVGVLDLCR DSEEVEAILN GDLESAEPLE
VHRHKASLSR VKLAIKYEVK KFVAHPNCQQ QLLTIWYENL SGLREQTIAI KCLVVLVVAL
GLPFLAIGYW IAPCSRLGKI LRSPFMKFVA HAASFIIFLG LLVFNASDRF EGITTLPNIT
VIDYPKQIFR VKTTQFTWTE MLIMVWVLGM MWSECKELWL EGPREYILQL WNVLDFGMLS
IFIAAFTARF LAFLQATKAQ QYVDSYVQES DLSEVTLPPE IQYFTYARDK WLPSDPQIIS
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVLFIMVF LAFMIGMFIL
YSYYLGAKVN AAFTTVEESF KTLFWSIFGL SEVTSVVLKY DHKFIENIGY VLYGIYNVTM
VVVLLNMLIA MINSSYQEIE DDSDVEWKFA RSKLWLSYFD DGKTLPPPFS LVPSPKSFVY
FIMRIINFSK CRQRRLQKDI EMGMGNSKSR FSKCFAVHLN LMQHCELNLF TQSNSRVFES
HSFNSILNQP TRYQQIMKRL IKRYVLKAQV DKENDEVNEG ELKEIKQDIS SLRYELLEDK
SQATEELAVL IHKLSEKLNP SMPRCE
//
