ID F6TJQ8_MOUSE Unreviewed; 129 AA.
AC F6TJQ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
DE Flags: Fragment;
GN Name=Mms19 {ECO:0000313|Ensembl:ENSMUSP00000133075.2,
GN ECO:0000313|MGI:MGI:1919449};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133075.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133075.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133075.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000133075.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133075.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBUNIT: Component of the CIA complex. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|RuleBase:RU367072}. Nucleus
CC {ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
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DR PeptideAtlas; F6TJQ8; -.
DR ProteomicsDB; 314573; -.
DR Antibodypedia; 30936; 186 antibodies from 27 providers.
DR Ensembl; ENSMUST00000169765.2; ENSMUSP00000133075.2; ENSMUSG00000025159.9.
DR AGR; MGI:1919449; -.
DR MGI; MGI:1919449; Mms19.
DR VEuPathDB; HostDB:ENSMUSG00000025159; -.
DR GeneTree; ENSGT00390000015583; -.
DR HOGENOM; CLU_1964596_0_0_1; -.
DR ChiTaRS; Mms19; mouse.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000025159; Expressed in embryonic post-anal tail and 257 other cell types or tissues.
DR ExpressionAtlas; F6TJQ8; baseline and differential.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF14500; MMS19_N; 2.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|RuleBase:RU367072};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367072};
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|RuleBase:RU367072};
KW Proteomics identification {ECO:0007829|EPD:F6TJQ8,
KW ECO:0007829|MaxQB:F6TJQ8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 10..77
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 77..129
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000133075.2"
FT NON_TER 129
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000133075.2"
SQ SEQUENCE 129 AA; 14512 MW; 0AD2E7A9ADDBCA9D CRC64;
XGGYTVLQVV EALGSSLENA EPRTRARGAQ LLSQVLLQCH SLLSEKEVVH LILFYENRLK
DHHLVVPSVL QGLRALSLLQ VDRHTVFSII TNFMRSREEE LKGLGADFTF GFIQVMDGEK
DPRNLLLAF
//
