ID F6TPE9_MACMU Unreviewed; 1087 AA.
AC F6TPE9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=DNA helicase B {ECO:0000313|Ensembl:ENSMMUP00000021866.4};
GN Name=HELB {ECO:0000313|Ensembl:ENSMMUP00000021866.4,
GN ECO:0000313|VGNC:VGNC:73185};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000021866.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000021866.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000021866.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6TPE9; -.
DR STRING; 9544.ENSMMUP00000021866; -.
DR PaxDb; 9544-ENSMMUP00000021866; -.
DR Ensembl; ENSMMUT00000023369.4; ENSMMUP00000021866.4; ENSMMUG00000016628.4.
DR VEuPathDB; HostDB:ENSMMUG00000016628; -.
DR VGNC; VGNC:73185; HELB.
DR eggNOG; ENOG502QWCN; Eukaryota.
DR GeneTree; ENSGT00390000006913; -.
DR HOGENOM; CLU_010264_0_0_1; -.
DR InParanoid; F6TPE9; -.
DR OMA; CTKNAYL; -.
DR OrthoDB; 5305157at2759; -.
DR TreeFam; TF336223; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000016628; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005662; C:DNA replication factor A complex; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0017116; F:single-stranded DNA helicase activity; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:Ensembl.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:1903775; P:regulation of DNA double-strand break processing; IEA:Ensembl.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR PANTHER; PTHR43788:SF21; DNA HELICASE B; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13604; AAA_30; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 880..926
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13538"
FT REGION 171..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 123310 MW; 2308BED86B0556A5 CRC64;
MARSSRYLRR LQGPLLPPKD LVEEDEDYLN DDVQEDEDSV FVDAEELCSG GVKAGSLPGC
IRVLIPDENT QETCKVLGRF PITGAWWRVK VQVKPVVGSR SYQYQVQGFP SYFLQSDMSP
PNQKHICALF LKECEVSSDV INKFLAWVNE VSNYKNLNFE NLRETLRTFH KETGRKDQKQ
PAQNGQEELF PDNEMSLPLE NKIPYRNVMT ALQFPKIMEF LPVLLPRHFK WLIESGSKEM
LKEIEEILGT HPWKLGFSKI TYRKWKLLRC EASWIAFYQC ESLLQLMTDL EKNALIMYSK
LKQICRELGH TYVEVNDLTL TLSDHMSFHA ASESLKFLKD IGVVTYEKAC VFLYDLYQAE
RAIAFSICDL MQRPPWRLCV DVKKVLASIH TTKPENSSDD ALNESKPDEA RLENPVDVVD
TQDSGDHIWT NGENEINAEI SEVQVDQDQA EVPLDRDQVA ALEMICSNPV TVISGKGGCG
KTTIVSRLFK HIEQLEEREV KNACEDFEQD QNASEEWNTF TEQSQLEAGK AIEVLLTAPT
GKAAGLLRQK TGLHAYTLCQ VNYSFYSWNQ TMMTTNKPWK FSSVRVLVVD EGSLVSVGIF
KSVLNLLCEH SKLSKLIILG DIRQLPSIEP GNLLKDLFET LKSRNCAIEL KTNHRAESQL
IVDNATRISR RQFPKFDAEL NISDNPTLPI SIQDKTFIFV RLPEEDASSQ SSKTNHHSCL
YSTVKTLLQE NDLQNAKTSQ FIAFRRQDCD LINDCCCKHY TGHLNKDHQN RLVFGVGDKI
CCTRNAYLSD LLPENISGSQ QNNDLDTSGE DFSGTLHDFA KNKHDFESNV RLCNGEIFFI
TNDVTDVTFG MRRSLTINNM AGLEVTVDFK KLMKYCRIKH AWARTIHTFQ GSEEQTVVYV
VGKAGRQHWQ HVYTAVTRGR CRVYVIAEES QLRNAIMKNS FPRKTRLKHF LQSKLSSSGA
PPADFQTPRK SSGDSGGPST PSASPLPVVT DHAMTNDVTW SEASSPDERT LTFAERWQLS
SPDGVDTDDD LPKSRASKRT CGVNDDESPS KILMVGESPQ VSSRLQNLRL NNLIPRQLFK
PTDNQET
//
