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Database: UniProt
Entry: F6TQ36_CIOIN
LinkDB: F6TQ36_CIOIN
Original site: F6TQ36_CIOIN 
ID   F6TQ36_CIOIN            Unreviewed;       725 AA.
AC   F6TQ36;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 2.
DT   08-MAY-2019, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000005564};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000005564, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Proteomes:UP000008144}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12481130; DOI=10.1126/science.1080049;
RA   Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B.,
RA   De Tomaso A., Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M.,
RA   Harafuji N., Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T.,
RA   Lemaire P., Martinez D., Meinertzhagen I.A., Necula S., Nonaka M.,
RA   Putnam N., Rash S., Saiga H., Satake M., Terry A., Yamada L.,
RA   Wang H.G., Awazu S., Azumi K., Boore J., Branno M., Chin-Bow S.,
RA   DeSantis R., Doyle S., Francino P., Keys D.N., Haga S., Hayashi H.,
RA   Hino K., Imai K.S., Inaba K., Kano S., Kobayashi K., Kobayashi M.,
RA   Lee B.I., Makabe K.W., Manohar C., Matassi G., Medina M.,
RA   Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA   Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA   Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A.,
RA   Stainier D., Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K.,
RA   Yoshizaki F., Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C.,
RA   Doggett N., Glavina T., Hawkins T., Richardson P., Lucas S.,
RA   Kohara Y., Levine M., Satoh N., Rokhsar D.S.;
RT   "The draft genome of Ciona intestinalis: insights into chordate and
RT   vertebrate origins.";
RL   Science 298:2157-2167(2002).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000005564}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15114417; DOI=10.1007/s00239-003-2559-6;
RA   Gissi C., Iannelli F., Pesole G.;
RT   "Complete mtDNA of Ciona intestinalis reveals extensive gene
RT   rearrangement and the presence of an atp8 and an extra trnM gene in
RT   ascidians.";
RL   J. Mol. Evol. 58:376-389(2004).
RN   [3] {ECO:0000313|Ensembl:ENSCINP00000005564}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; EAAA01002457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EAAA01002458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCINT00000005564; ENSCINP00000005564; ENSCING00000002726.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00950000183084; -.
DR   InParanoid; F6TQ36; -.
DR   OMA; ESFMRTN; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR   CDD; cd00033; CCP; 1.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00084; Sushi; 1.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00032; CCP; 1.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00179; EGF_CA; 1.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   SUPFAM; SSF57535; SSF57535; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS50923; SUSHI; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008144};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00037407};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW   Repeat {ECO:0000256|SAAS:SAAS00792548};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    725       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003343512.
FT   DOMAIN       16    149       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      201    320       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      322    388       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      482    722       Peptidase S1. {ECO:0000259|PROSITE:
FT                                PS50240}.
FT   DISULFID    359    386       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   725 AA;  81561 MW;  11EF6E9B379A2D57 CRC64;
     MKRLYLLLFL FAVGEARRVV KTGNFGFLTS TGYPQPYGNN LNDTWTITVN RGYRVVLYFT
     AFDLEDSFAN GEVCGLDYLQ IIDGPLSSNQ TQGKYCGNPI MFWEDAPALV SQKFRSSAQV
     LSLRMVSDFS NDLPMTSPPV GFKAHYYAED RNECTELREA YDKSDEPESV GKCDHYCNNY
     PGGFYCSCKA GYRLHENGYT CTGLCQDVTI LQHEGIITSP GYPSNYPRLT DCNWHIETDA
     GKTIHFQFNR NFHVEAHDTG ACAYDWLKIR DNSGETGPFC GDQAPSNGAE IITTTNWFEI
     QFHSDAEVEQ PGFSLSYRTH DIRCLVPPPP MHGYILSPSL ADPMGENYVS FGGLIRYDCN
     MGFRVIGSAK LLCLKDGSMS DDAPVCEMPI CGKESRNLLN FQFRKTSIIN IMSFRNSRVG
     YICMYIYVAQ QTLCTPRPIV QITYTCTRRV LIWTWKTESK HDNFLYTLFQ CGKSIPRPSP
     KIIGGRWAGP GEYPWMVQIT TNDEHAVCGA TLICSNWVVT AAHCFLKKRG TLVMPNPIDK
     LQYLIHVGKY WKYGQQDRRR VQTYRASRII IHPQYNHRND REDIALIELD GYVADMTHAR
     PICLPSTNGY PNVGDTCKAL GWGITRNIGP SATILKELDM VVAAGSGCAS YHDYNWRKIL
     CAGGEAGRDT CKGDSGGPFL CITNSRWYIH GITSFGHGCA RGVPGGYTRV SNYINWIRLH
     IGQLC
//
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