ID F6TQD8_HORSE Unreviewed; 1130 AA.
AC F6TQD8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Solute carrier family 9 member C1 {ECO:0000313|Ensembl:ENSECAP00000018463.2};
GN Name=SLC9C1 {ECO:0000313|Ensembl:ENSECAP00000018463.2,
GN ECO:0000313|VGNC:VGNC:57098};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018463.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018463.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018463.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018463.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018463.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6TQD8; -.
DR Ensembl; ENSECAT00000022349.3; ENSECAP00000018463.2; ENSECAG00000020986.4.
DR VGNC; VGNC:57098; SLC9C1.
DR GeneTree; ENSGT00940000162055; -.
DR HOGENOM; CLU_003400_1_1_1; -.
DR TreeFam; TF328865; -.
DR Proteomes; UP000002281; Chromosome 19.
DR Bgee; ENSECAG00000020986; Expressed in testis.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF87; SODIUM_HYDROGEN EXCHANGER 10; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF00999; Na_H_Exchanger; 2.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 643..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 841..949
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1079..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 129729 MW; F8848DC61F712B0E CRC64;
MTSSSGLSNL SFLNKGSTGP WMDLFRTGIE NQSEGLPEII LILSLICTVG AFLNLHLKDF
PIPLPVILFF IGCSFEMLSF TSDQVQRYAD AIQWIDPGLF FDIFTPIIIF NVAFDMDVYM
LNKLFWQILL ITIPGFIMNY ILILWYLASM NKLLLKTSPW LLFAAILVSS DPMLTATAIR
DLGLSRGLVN LINGESLMTS IMSLITFTGI VHIKSGMQRK TNYSLAELVG MSGIFTLAIM
GLFLNSTSFK PGVEALLLEF WNCLSFAAFL MVFTFIGLLI PAHTYLYISF SDIYYSLNIY
LTLIVLRLLV FLFMSPLLSR LGDGFSWRWA FIMAWSEMKG MPNINMALLF AYSDHFLGSE
REKSQVLFHA VAVCLVSLIV NRLILPIAVS KLGLRDVTST KYKSLYCTFQ HFQEVTRSAA
SALKFDKDLA DADWNMVEKA IVLQNPYALS QGETTEHQKV KCPDCNKEID ETLNIEAMEL
ANRRLLSAQI ASYQRQYRNE TLSQNAVQVL VGVAGSFGEK KGEHVSPETI KNYSESKKIL
SFIRKVLLNW VYNTKKEKGV PSRHFFLRIC HKIVFTDEFE YVGYLVILMN LFPIIISWIP
GLNTIYEQEL RHSNYSFLAF YILEALLKIA AMRKKYVSHT WNLFELAITI VGIIDVILIE
TNSIDYTFDL IQTMVFIKIV RLFRILRILK LVTPKLLQII DKKMSHQLSF RYAILKGYVQ
GEADIMTIID QIASSKQVKK MLLSRLTRNT GHAMKELGYL EYDHPEIVVT MKTKEEILVM
LSLAREIVRV FRLKGIIHKI EGSEINKLIM AKKQEILDFQ PIIKPLTVEE ALYHIPWLDK
DEDHINFIQE RAKVVTFDCG NDIFEEGDEP KGIYIIISGM VKLQRSKPGL GIDQVLWETE
EKDYPITYTD FLISGEIIGE LNCLTNEPMK YSATCKTVVE TCFIPKRDLY EAFEQYYPHI
EYKMWLKLGL SITAQKIRGH LSYEDWNYKM QLKLCNVCVK DIPQNIKTDM YDETVIYVIL
IHGALEDCQL RKAYKAPSLI PLTCHQVQGT EDFTKVMIVQ TPVDLKKFRW NTRKYVSSRK
PSLPEESAST EKIQEEHPED ETGIEVEQPT ELLDNVEEMK IDDVNEKKPK
//
