ID F6TRE5_XENTR Unreviewed; 554 AA.
AC F6TRE5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Neurofilament light polypeptide {ECO:0000256|ARBA:ARBA00019275};
DE AltName: Full=Neurofilament triplet L protein {ECO:0000256|ARBA:ARBA00033132};
GN Name=nefl {ECO:0000313|Ensembl:ENSXETP00000022374,
GN ECO:0000313|RefSeq:XP_002932628.2,
GN ECO:0000313|Xenbase:XB-GENE-492106};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000022374};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000022374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000022374};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000022374}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002932628.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002932628.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002932628.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_002932628.2; XM_002932582.5.
DR STRING; 8364.ENSXETP00000022374; -.
DR Ensembl; ENSXETT00000022374; ENSXETP00000022374; ENSXETG00000010142.
DR GeneID; 100216135; -.
DR KEGG; xtr:100216135; -.
DR AGR; Xenbase:XB-GENE-492106; -.
DR CTD; 4747; -.
DR Xenbase; XB-GENE-492106; nefl.
DR HOGENOM; CLU_012560_7_3_1; -.
DR OMA; YGRAQVS; -.
DR OrthoDB; 4640531at2759; -.
DR PhylomeDB; F6TRE5; -.
DR TreeFam; TF330122; -.
DR Reactome; R-XTR-438066; Unblocking of NMDA receptors, glutamate binding and activation.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000010142; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF8; NEUROFILAMENT LIGHT POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 86..396
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 452..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..173
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 202..240
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 315..374
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 463..541
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 62732 MW; F24D7EDDBB86DF43 CRC64;
MSSYSYDPYY TSYKRRVVES SPRVHIRSSY VSPSRTTYSP VVSSTMRRSY AASSSSSSSL
LHGVDTMDLS QVAAISSDLK IVRTQEKAQL QDLNDRFANF IERVHELEQR NKVLEAELLL
LRQKHNEPSR LRDLYEQEVR ELRLAQEEAT GDRQTMRNER ERLEDALRLL QGRYEEEALS
REDAEARLLD VRKEADMAAL ARVELEKRMD SLLDEIAFLK KVHEEELAQL QSQVQYAQIS
LEVEVAKPDL SSALRDIRAQ YEKLAAKNMQ SAEDWFKSRF TVLTQSAARN TDAVRAAKDE
VSESRRMLSA KGLEIEACRG VNDALERQIQ ELEEKQSGEI AGMQDAINKL EEELRNTKSE
MARYLKEYQD LLNVKMALDI EIAAYRKLLE GEETRLSFSG VGAITSGYTQ SAPVFGRSAY
SLQSSSYMTS RAFPTYYSSH VQEEQLDIEE TIESSRAEEA KAEAPEEEEE EAGEEEAEGG
EGDEGEGEEG EEAKEEEAEE EGEGEEKEEE EEGEGEAEGE AEGEGEAEGE GEEEEEGKGE
EPAEEESKKK EKKK
//
